Kach: GI secretions

Question 1

Histamine-2 receptors

Answer 1

When stimulated release hydrochloric acid

Question 2

Swallowing is controlled by …

Answer 2

The medulla

Question 3

Vomiting is controlled by…

Answer 3

The CTZ in the medulla

Question 4

These medications block the release of Hydrochloric acid in response to Gastin

Answer 4

H² Antagonist

Question 5

Cimetidine
Famotidine
Nizatidine
Ranitinde

Are examples of this medication

With this effect

Answer 5

Histamine ² Antagonist

Block the release of Hydrochloric acid in response to gastrin

Question 6

____ work to suppress the secretion of Hydrochloric Acid into the Lumen of the stomach

Answer 6

PPI

( - azole)

Question 7

Sucralfate

Answer 7

GI protectant coat the stomach and prevent further injury from acid

Question 8

____ inhibit the secretion of gastrin and increase secretion of mucous liming

Answer 8

Prostaglandin

misoprostol

Question 9

Cimetidine
Famotidine
Nizatidine
Ranitinde

Are examples of…
With what effect

Answer 9

Histamine ² Antagonist

Block release of Hydrochloric acid in response to gastrin

Question 10

Famotidine (Pepcid AC)
Nizatidine (Axid AR)
Cimetidine (Tagamet HB)
Ranitinde (Zantac)

Are examples of

Answer 10

H² ANTAGONIST

Block release of Hydrochloric acid in response to gastrin

Question 11

High levels of H² Antagonist can cause

Answer 11

Cardiac arrhythmias

Question 12

Adverse effects

Diarrhea/ Constipation

Dizzy, headache, confusion, somnolencia, confusion, Hallucinations

Cardiac arrhythmias & Hypotension

Gynecomastia & Impotence

Answer 12

H² Antagonist

Question 13

Drug interactions

Anticoagulant
Beta blockers
Alcohol
Quinididine, lidocaine, theophylline, chloroquine,
Benzodiazepine
Tri cyclic antidepressants

Nifedipine, pentoxifylline, Procainamide, carbamazepine

Answer 13

H² Antagonist

Question 14

Used for:

Short term treatment Duodenal or benign gastric ulcers

Treat pathological hypersecretory conditions

Prophylaxis stress induced ulcers

Erosive GERD

Relief symptoms heartburn & acid indigestion

Answer 14

H² Antagonist

(-tidine)

Question 15

This GI medicine can cause serious electrolyte imbalance in persons with rental impairment

Answer 15

Sodium Bicarbonate

Question 16

Main drawbacks for this anti acid are Constipation & Acid rebound

Answer 16

Calcium Carbonate

Question 17

Magnesium Salt antacids have this side effect

Answer 17

Diarrhea

Question 18

Heart failure can occur with this antacid

Answer 18

Sodium Bicarbonate

Due to water retention

Question 19

Which type of GI medication can interfere with the absorption of other medication.

Due to changing the environment of the stomach

Answer 19

Antacids

Turn it Alkaline

Question 20

Treats

Upset stomach from hyperacidity

Prophylaxis for GI bleed / stress ulcer

Severe diarrhea

Metabolic acidosis

Certain drug intoxication

Answer 20

Antiacids

Question 21

Gastric rupture

Systemic Alkalosis
(Headache/nausea, irritation, weakness, tetany, confusion)

Hypokalemia

Gastric acid rebound

Answer 21

Antacids

Question 22

Omeprazole (Prilosec)
Esomeprazole (Nexium)
Iansoprazole (Prevacid)
Dexlansoprazole (Dexilant)
Pantoprazole (Protonix)
Rabeprazole (Aciphex)

How do they work

Answer 22

PPI

Supress secretion of Hydrochloric acid into the Lumen of the stomach

Question 23

Supress gastric secretion by inhibition of the hydrogn-potassium adenosine triphosphate on surface of gastric parietal cells

Blocking the final step in Acid production

Answer 23

PPI

(-Prazole)

Question 24

Treats

Duodenal ulcers
GERD
Errosive esophagitis
Benign active gastric ulcers

Long-term
Hypersecretory conditions
Maintenance of erosive esophagitis & ulcers

Used in combination with antibiotics for treatment of H pylori

Answer 24

PPI

(Prazole)

Question 25

Contradictions Don't use with rilpivirine (It can treat HIV infection)

Answer 25

PPI (-Prazole)

Question 26

Side effects: Diarrhea, cramps, N/V, Insomnia, Vertigo Tongue atrophy Alopecia, Pruritus Increase Bone Loss Cancer

Answer 26

PPI (-Prazole)

Question 27

Increased toxicity with use of Benzodiazepine, phenytoin, warfarin Decreased levels of Ketoconazole ( Antifungal) Theophylline (Bronchodilator) Don't use with antiretroviral drugs Atazanavir Nelfinavir Saquinavir Rilpivirine

Answer 27

PPI (-Prazole)

Question 28

Sucralfate (carafate) is....

Answer 28

GI Protectant Coat injured area and prevent further acid damage

Question 29

Adverse effects associated with Sucralfate (Carafate)

Answer 29

Mostly GI

Question 30

Sucralfate (GI protectant) Should not be given with this due to potentially Toxic combinations

Answer 30

Aluminum Salts Used in Antacids Deodorant Vaccines

Question 31

Treats Short term and maintenance of active duodenal ulcers Oral & esophageal ulcers due to radiation, chemotherapy, sclerotherapy

Answer 31

Sucralfate (Carafate) GI protectant

Question 32

Forms an ulcer-adherent complex at the duodenal ulcers site, protecting it from bile,acid,salts, pepsin & Promotes Healing of Ulcer Inhibits pepsin activity in gastric juices

Answer 32

Sucralfate (carafate) GI protectant

Question 33

Inhibits gastric acid secretion and increases bicarbonate and mucous production Protects the stomach

Answer 33

Prostaglandins Misoprostol (Cytotec)

Question 34

Primary use to prevent NSAID-induced gastric ulcers

Answer 34

Prostaglandin Misoprostol (cytotec)

Question 35

These GI drugs that inhibit gastric secretions and increase bicarbonate/ mucous production can INDUCE MISCARRIAGES

Answer 35

Prostaglandins Misoprostol (cytotec)

Question 36

Saliva substitute should be avoid by these types of patients

Answer 36

HF, HTN, renal failure due to it makes the body absorb more Na

Question 37

Pancreatitic enzymes should be avoided by patients with these allergies

Answer 37

Pork

Question 38

misoprostol (class) Do not give to..

Answer 38

Prostaglandins Pregant women