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Flashcards in Konorev, Clinical Uses Deck (56)
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1

Adrenergic Agonists - Cardiovascular conditions
To increase BP in hypertensive emergencies - hemorrhagic shock, overdose of antihypertensives, CNS depressants

Norepinephrine (a1,2 B1)
Phenylephrine (a1)
Methoxamine (a1)

2

Adrenergic Agonists - Cardiovascular conditions
Chronic hypOTension

Ephedrine (indirect - releases stores catas and direct adrenergic agonist)

3

Adrenergic Agonists - Cardiovascular conditions
Cardiogenic shock - due to massive acute myocardial infarction

Peripheral mimetic action? Y/N
Beta1 mimetic aciton? Y/N

Dopamine (D1, D2)
Dobutamine (B1)

Peripheral mimetic action? No
Beta1 mimetic action? Yes

4

Adrenergic Agonists - Cardiovascular conditions
Heart failure - drug for short term use in acute HF

Dobutamine (B1)

5

Adrenergic Agonists - Cardiovascular conditions
Heart failure - ___ in severe CHF with reduced renal perfusion

Dopamine (D1, D2)

6

Adrenergic Agonists - Cardiovascular conditions
HTN - long term tx

alpha 2 agonists
(clonidine)

7

Adrenergic Agonists - Cardiovascular conditions
HTN emergencies

fenoldopam (D1)

8

Adrenergic Agonists - Cardiovascular conditions
Emergency therapy for complete AV block and cardiac arrest

Epinephrine (all adrenergic)
Isoproterenol (B1, B2)

9

Adrenergic Agonists - Cardiovascular conditions
Decongestion of mucous membranes

Phenylephrine (a1)
Ephedrine and Pseudoephedrine (indirect - releases stores catas and direct adrenergic agonist)

10

Adrenergic Agonists - Bronchial asthma
Beta-2 selective agonists

Albuterol (B2)
Terbutaline (B2)

11

Adrenergic Agonists - Anaphylaxis (type I) intermediate allergic reaction with respiratory and CV componenets

Epinephrine (all adrenergic)

12

Adrenergic Agonists - Anaphylaxis
Respiratory component

bronchospasm and upper airway congestion

13

Adrenergic Agonists - Anaphylaxis
CV component

severe hypOTension, cardiac depression

14

Adrenergic Agonists - ophthalmic applications
Examination of retina - induction of mydriasis

Phenylephrine (a1)

15

Adrenergic Agonists - ophthalmic applications
Glaucoma - alpha-2 selective agonist

Apraclonidine (a2)
Brimonidine (a2)

16

Adrenergic Agonists - GI
Suppression of premature labor - beta-2 agonist

Terbutaline (B2)

17

Indirect Adrenergic Agonists - GI
Stress incontinence

Ephedrine

18

Adrenergic Agonists - GI
Priapism - alpha-1 agonist (injeciton into penis)

Phenylephrine (a1)

19

Indirect Adrenergic Agonists - CNS conditions
Narcolepsy

Amphetamines
Methylphenidate

20

Indirect Adrenergic Agonists - CNS conditions
ADHD

Methylphenidate

21

Adrenergic Agonists - CNS conditions
Obesity - inhibition of appetite and increased energy expenditure

Phentermine
Ephedrine
Amphetamines

22

Adverse Effects of Adrenergic Agonists
CV adverse effects

Elevated BP
MI, HF - esp elderly
Sinus tach, vent arrhythmia
Direct myocardial damage
Cardiac DEATH

23

Age group to be cautious with adrenergic agonists

elderly and pts with HTN, CAD, CHF

24

Adverse Effects of Adrenergic Agonists
CNS toxicity

Amphetamine
Cocaine

25

What types of agonist drugs do not cause CNS toxicity

Polar (dont cross BBB)
Catecholamines

26

Amphetamine CNS toxicity causes:

Insomnia
Lack of appetite
Anxiety, restlessness
Psychoses (apranoid, hallucinations)

27

Cocaine CNS toxicity causes:

Convulsions
Arrhythmias
Hemorrhagic stroke

28

Alpha Antagonists - Pheochromocytoma presents with

tachy, arrhythmia, HTN

29

Alpha Antagonists - Pheochromocytoma Tx

Phentolamine
Phenoxybenzamine

30

Alpha Antagonists - chronic HTN tx

Prazosin
Terzosin
Doxazosin