Flashcards in L 23 Deck (13)
What TF controls Treg development? Cytokines?
What TF controls Th1 development? Cytokines?
What TF controls Th2 development? Cytokines?
What TF controls Th17 development? Cytokines?
What is indirect allograft rejection?
Donor cells died
Digested & presented by recipient APC (MHC2)
What is direct allograft rejection?
Donor APCs (MHC2) are recognized by recipient APCs
What are the 3 immune responses that lead to graft rejection?
1. DTH - activated macrophages
2. Abs against graft
3. CD8 direct killing graft
Is indirect or direct presentation linked to acute cellular rejection?
What type of injury are you concerned about with a transplanted organ? Which type of immunity does this trigger?
From a dead donor - guaranteed some level of inflam
Will trigger innate immunity when transplanted
What is hyperacute rejection?
Patient who has been immunized to a donor
PREVENTABLE - this should never happen!!!!!!
What is chronic rejection?
B cell Abs continuously attack the allograft over time
Cells killed --> fibroblasts --> organ loses fxn over time
This is still an issue b/c we don't have good drugs to interrupt B cells
What are some drugs you can use for immunosuppression post transplant?
mAbs vs IL 2-R