Flashcards in L 23 Deck (13)
1
What TF controls Treg development? Cytokines?
FoxP3
IL 10
TGF beta
2
What TF controls Th1 development? Cytokines?
T-bet
IL 12
IFN gamma
3
What TF controls Th2 development? Cytokines?
GATA 3
IL 4
4
What TF controls Th17 development? Cytokines?
ROR
IL 6
IL 21
5
What is indirect allograft rejection?
Donor cells died
Digested & presented by recipient APC (MHC2)
6
What is direct allograft rejection?
Donor APCs (MHC2) are recognized by recipient APCs
7
What are the 3 immune responses that lead to graft rejection?
1. DTH - activated macrophages
2. Abs against graft
3. CD8 direct killing graft
8
Is indirect or direct presentation linked to acute cellular rejection?
Direct
9
What type of injury are you concerned about with a transplanted organ? Which type of immunity does this trigger?
Ischemia reperfusion
From a dead donor - guaranteed some level of inflam
Will trigger innate immunity when transplanted
10
What is hyperacute rejection?
Patient who has been immunized to a donor
IMMEDIATE rejection
PREVENTABLE - this should never happen!!!!!!
11
What is chronic rejection?
B cell Abs continuously attack the allograft over time
Cells killed --> fibroblasts --> organ loses fxn over time
This is still an issue b/c we don't have good drugs to interrupt B cells
12
What are some drugs you can use for immunosuppression post transplant?
mAbs vs IL 2-R
Belatacept
13