L 23 Flashcards Preview

Immunology > L 23 > Flashcards

Flashcards in L 23 Deck (13)
1

What TF controls Treg development? Cytokines?

FoxP3
IL 10
TGF beta

2

What TF controls Th1 development? Cytokines?

T-bet
IL 12
IFN gamma

3

What TF controls Th2 development? Cytokines?

GATA 3
IL 4

4

What TF controls Th17 development? Cytokines?

ROR
IL 6
IL 21

5

What is indirect allograft rejection?

Donor cells died
Digested & presented by recipient APC (MHC2)

6

What is direct allograft rejection?

Donor APCs (MHC2) are recognized by recipient APCs

7

What are the 3 immune responses that lead to graft rejection?

1. DTH - activated macrophages
2. Abs against graft
3. CD8 direct killing graft

8

Is indirect or direct presentation linked to acute cellular rejection?

Direct

9

What type of injury are you concerned about with a transplanted organ? Which type of immunity does this trigger?

Ischemia reperfusion
From a dead donor - guaranteed some level of inflam
Will trigger innate immunity when transplanted

10

What is hyperacute rejection?

Patient who has been immunized to a donor
IMMEDIATE rejection
PREVENTABLE - this should never happen!!!!!!

11

What is chronic rejection?

B cell Abs continuously attack the allograft over time
Cells killed --> fibroblasts --> organ loses fxn over time
This is still an issue b/c we don't have good drugs to interrupt B cells

12

What are some drugs you can use for immunosuppression post transplant?

mAbs vs IL 2-R
Belatacept

13

Describe features of patients that are high risk for rejection.

Not 1st transplant
Black/hispanic
Dead donor
Poor HLA match