L 26, 27 Antidepressants

Question 1

What are the 5 classes of Antidepressants?

Answer 1

Tricyclics

SSRI

SNRI

Atypical or Misc

MAOI

Question 2

Tertiary Tricyclics MOA?

Answer 2

inactivate “amine” pump on PREsynaptic

(-) NE, SE reuptake

Question 3

What drugs are Tertiary Amine Tricyclics?

Answer 3

amitryptyline

clomipramine

doxepin

impiramine

trimipramine

Question 4

What drugs can be given I.M?

Answer 4

amitryptyline

imipramine

Question 5

Clomipramine therapeutic use?

Answer 5

OCD

Question 6

Clomipramine SE?

Answer 6

seizure

Question 7

Doxepin therapeutic use? SE?

Answer 7

increased sedation

no cardio SE

Question 8

Trimipriamine therapeutic use?

Answer 8

very sedating

moderately anticholinergic

Question 9

What drugs are secondary Amine Tricyclics?

Answer 9

amoxapine

desipramine

maprotilline

nortyptyline

protryptyline

Question 10

Amoxapine MOA?

Answer 10

dopaminergic & adrenergic

Question 11

Nortryptyline indications?

Answer 11

elderly

Question 12

What drugs are 1st choice for Monopolar depression?

Answer 12

SSRI

Question 13

What drugs are SSRI?

Answer 13

citalopram
escitalopram

fluoxetine
fluvoxamine

paroxetine
sertaline

Question 14

What drugs are SNRI?

Answer 14

duloxetine
milnacipran

venlafaxine
desvenalfaxine

Question 15

SNRI MOA?

Answer 15

(-) SE & NE reuptake

Question 16

What drugs Tx fibromyalgia?

Answer 16

duloxetine

milnacipran

Question 17

What drugs are atypical?

Answer 17

bupropion
mirtazapine

trazadone
vilazodone

Question 18

Bupropion MOA?

Answer 18

(-) DA, NE reuptake

Question 19

Trazadone indications?

Answer 19

psych pt sleep at night in hospital

Question 20

MAOI indications?

Answer 20

tx resistant depression

refractory depression

Question 21

MAOI MOA?

Answer 21

inactivate enzyme that metabolizes NE & SE

Question 22

What drugs are MAOI?

Answer 22

isocarboxazid

phenelzine

tranylcpromine

Question 23

What is the Tx for Bipolar Disorder?

Answer 23

mood stabilizers

Question 24

What are Anti depressants drug interactions?

Answer 24

CNS Depressants
MAO(-)

Amphetamine
Tryamine
Anesthetic w/ EPI

Pseudoephedrine

Question 25

Lithium MOA?

Answer 25

(-) nerve metabolism (-) Inositol monophosphatase alters reputake of SE, NE, DA Dec. Ptn Kinases

Question 26

Lithium SE?

Answer 26

compliance GI-- Nausea, Diarrhea Drowsy Polyuria Dry mouth, thirsty Nephrogenic Diabetes Wt. Gain Insomnia Thyroid Enlargement

Question 27

What drugs Inc excretion of Lithium?

Answer 27

osmotic diuretics acetazolamide

Question 28

What drugs Dec Lithium excretion?

Answer 28

thiazides & loop diuretics

Question 29

What happens if Lithium is combined with NSAIDs such as indomethacin, naproxen, ibuprofen?

Answer 29

dec clearance Inc reabsorption -> toxicity

Question 30

Lamotrigine therapeutic use?

Answer 30

long term prophylactic tx bipolar w/out acute mania

Question 31

Valproic Acid therapeutic use?

Answer 31

mania

Question 32

Carbamazepine therapeutic use?

Answer 32

tx resistance bipolar

Question 33

What drugs are used for maintenance therapy?

Answer 33

olanzapine aripiprazole risperidone quetiapine lurasidone

Question 34

Secondary Amine Tricyclics MOA?

Answer 34

(-) NE reuptake

Question 35

SSRI MOA?

Answer 35

(-) SE reuptake