L 31 Chemotherapeutics

Question 1

Antimetabolites MOA?

Answer 1

interfere with DNA synthesis

S phase specific

Question 2

Antimetabolites effective for?

Answer 2

rapidly proliferating tumors

leukemia, lymphomas

Question 3

What do Antimetabolites cause?

Answer 3

myelosuppression

Question 4

What drug is an Antimetabolite?

Answer 4

Methotrexate

Question 5

Admin Methotrexate with?

Answer 5

Leucovorin

-> protect from cytotoxicity

Question 6

What are the Microtubule Inhibitors?

Answer 6

Vina Alkaloids
-> Vincristine, Vinblastine

Taxanes
-> Paclitaxel, Docetaxel

Question 7

Vincristine Tx?

Answer 7

pediatric leukemias, solid tumor, adult lymphomas

Question 8

Vinblastine Tx?

Answer 8

testicular cancer, lymphomas

Question 9

Microtubule Inhibitors have acquired resistance due to?

Answer 9

MDR-1 Gene

Question 10

What drug is Topoisomerase Inhibitors?

Answer 10

Etoposide

Question 11

What is Topoisomerase required for?

Answer 11

mitosis

Question 12

Antibiotics MOA?

Answer 12

intercalate into DNA = prevent transcriptions

= DNA strand breaks
Cell cycle non specific

Question 13

What are the DNA Intercalating/Damaging drugs?

Answer 13

Bleomycin

Question 14

Alkylating Agents MOA?

Answer 14

cross link DNA

= prevent gene expression
= apoptosis

cell cycle specific

Question 15

What can Alkylating Agents induce?

Answer 15

leukemia

Question 16

What drugs are Alkylating Agents?

Answer 16

Nitrogen Mustards

Platinum Compounds

Nitrosoureas

Alkyl Sulfonates

Question 17

What drug is a Nitrogen Mustard?

Answer 17

Cyclophosphamide

Question 18

Cyclophosphamide Tx?

Answer 18

Burkitt’s Lymphoma

Question 19

Cyclophosphamide SE?

Answer 19

potent immunosuppression

Question 20

What drugs are Platinum Compounds?

Answer 20

Cisplatin

Carboplatin

Question 21

Cisplatin combo? Tx?

Answer 21

w/ bleomycin, etoposide, vinblastine

Testicular Cancer

Question 22

Carboplatin combo? Tx?

Answer 22

w/ paclitaxel, cyclophosphamide

Ovarian Cancer

Question 23

Rationally Designed Chemotherapeutics MOA?

Answer 23

targeted to the causative molecular abnormality

Question 24

What drug is a Rationally Designed?

Answer 24

Imatinib

Question 25

Imatinib MOA?

Answer 25

(-) bar-abl tyrosine kinase causative only in chronic myelocytic leukemia

Question 26

How can tumor cell growth/ survival be inhibited?

Answer 26

lowering hormone levels antagonizing hormone function

Question 27

What is 1st choice for hormonal therapy of estrogen receptor breast cancer?

Answer 27

Tamoxifen

Question 28

Tamoxifen & Raloxifene Tx?

Answer 28

breast cancer prevention for high risk pt

Question 29

Anti-estrogen drugs?

Answer 29

Tamoxifen Raloxifene

Question 30

Anti-Estrogen MOA?

Answer 30

(-) binding of estradiol to the ER and gene transcription

Question 31

Anti-Estrogens are less effective in?

Answer 31

premenopausal bc high estrogen ER-negative tumors

Question 32

Anti-Androgen Tx?

Answer 32

prostate cancer

Question 33

What are Anti-Androgen drugs?

Answer 33

Cyproterone -- Steroidal bicalutamide -- Non

Question 34

Steroidal Anti-Androgen MOA?

Answer 34

(-) androgen binding to the AR

Question 35

Non Steroidal Anti-Androgen MOA?

Answer 35

(-) nuclear translocation of AR

Question 36

Anti-Androgens inhibit?

Answer 36

AR Dependent gene transcription

Question 37

What are the Immunotherapy drugs?

Answer 37

Rituximab Trastuzumab

Question 38

Rituximab MOA?

Answer 38

binds CD20 on non Hodgkins

Question 39

Trasruzmab MOA?

Answer 39

antibody to human epidermal growth factor receptor 2

Question 40

Trastuzumab Tx?

Answer 40

breast cancers over expressing HER2

Question 41

Rituximab SE?

Answer 41

tumor lysis syndrome