L 32 Asthma & COPD Flashcards
(28 cards)
What do Rescue Meds do?
short acting tx symptoms AFTER they have started
What do Controller Meds do?
long acting PREVENT symptoms before they start
Short-acting Beta Agonist MOA?
Inc. cAMP = SM relax
Short-acting Beta Agonist SE?
tremor
tachycardia
Long-acting Beta Agonist MOA?
Inc. cAMP = SM relax
Long-acting Beta Agonist contraindications?
single agent in asthma
Anticholinergics MOA?
(-) M3 receptors on SM
= (-) bronchoconstriction
Anticholinergics contraindications?
glaucoma
prostate hypertrophy
Corticosterioids MOA?
alter gene transcription
= less infl.
Corticosteroids SE?
pneumonia
osteoporosis
oral thrush – rinse after use
cataracts
voice change
Combine Long-acting Beta Agonist with?
corticosteroids
Leukotriene inhibitor MOA?
(-) LTE receptors
or
(-) leukotriene synthesis
Methylxanthines MOA?
(-) PDE
(-) Adenosine
activate histone deacetylase
Anti- IgE MOA?
(-) IgE from pro inflammatory signaling
Anti-IgE indications?
moderate - severe asthma
high IgE
allergies
Anti- IL5 MOA?
IL-5 receptor antagonist
- eosinophil production
Anti- IL5 Indications?
moderate - severe asthma
high eosinophil count
What are the cornerstone of therapy for asthma?
inhaled corticosteroids
What is the 1st line therapy for COPD?
LABA
or
Anticholinergic
What are COPD medications?
Beta Agonists
Anti Cholinergic
Inhaled Corticosteroids
Theophylline
PDE4 (-)
PDE4 (-) MOA?
Inc. cAMP = anti infl. effects
PDE4 (-) SE?
GI upset
Diarrhea
Wt. Loss
What treats severe COPD?
inhaled corticosteroids
What are controller meds for COPD?
LABA / LAMA combo
