L5-6 Acid-Base Balance Flashcards Preview

BMS242 CVS Phys > L5-6 Acid-Base Balance > Flashcards

Flashcards in L5-6 Acid-Base Balance Deck (102)
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1

Describe the pH scale

Logarithmic and reciprocal

2

Fall in pH leads to ________ in H+

Increase

3

Rise in pH leads to ________ in H+

Decrease

4

What would the result of a 1 unit pH change be in H+

x10 change

5

Why must pH be carefully controlled

A small pH change will have profound phyisological effects

6

Normal pH range

7.35 - 7.45

7

Describe the effects fluctuations in H+ may have

Change the excitability of muscles/nerves
Enzyme activities changed
Change in K+ levels

8

What organ does hyperkalaemia have a hug effect on in praticular

Heart

9

pH of gastric secretions

0.7

10

pH of CSF

7.3

11

pH of pancreatic secretions

8.1

12

pH of the final urine

5.4

13

How many moles of CO2 metabolised per day

15

14

Diet is a huge source of

Acid

15

How many mmol net H+ due to metabolism

40

16

One source of alkali

Fruit

17

Western diet contributes to

Excess ingestion of acid

18

How many mmole of H+ in per day through diet

20

19

Net H+ gain per day

70 mmol

20

3 Systems involved in the control of acid-base balance

Blood and tissue buffers
Respiration
Renal

21

Which is the only method which directly allows the extrusion of H+/OH-

Renal

22

Examples of buffers

Hb HCO3- Pi Weak acids/bases on proteins

23

Equation for the primary ECF buffer

CO2 + H2O H2CO3 HCO3- + H+

24

What is the name of the primary ECF buffer

Carbonic acid/bicarbonate buffer

25

Describe what would happen to the Carbonic acid/bicarbonate buffer if there was an increase in CO2

Eqbm shift right to minimise change
More H+ produced

26

What is the equation for pH in the Carbonic acid/bicarbonate buffer system

Ph = pK + [HCO3/H2CO3]

27

What can be said about the concentrations of H2CO3 + CO2 at eqbm

Equal

28

Rewrite the equation of the Carbonic acid/bicarbonate buffer system to include CO2

pH = pK + [HCO3/CO2]

29

What is pK at 37 deg

6.1

30

Describe what would happen to the Davenport diagram if acid was added

Conc of HCO3- decreases
pH decreases
Metabolic acidosis