L5- parmacokinetics Flashcards
(7 cards)
1
Q
F
A
Fraction of dose absorbed and passed through liver into systemic circulation
2
Q
Vol of distribution
A
How well the drug distributes into circulation
3
Q
What does vol of d depend on
A
Physiochemical properties, tissue binding, plasma protein binding, weight
4
Q
Clinical characteristics which effect clearance
A
Weight, liver function, age, enzyme activity, drugs foods and environmental factors which effect enzyme activity, kidney function
5
Q
What is clearance
A
The volume cleared of drug per unit time
6
Q
Units for dosing rate
A
Mg/ day
7
Q
t
A
Dosage interval
