L6 Hemostasis

Question 1

proteins facilitate Platelet Adhesion on the injured site

Answer 1

vWF and Collagen

Question 2

Hemostasis is a Reversible Process. Why?

Answer 2

Due to Coordination between Coagulation and Inherent Fibrinolytic Activity

Question 3

Components of the Primary Hemostasis Events

1- Cells are … and …

Answer 3

Endothelial cells, Platelets

Question 4

Adhesive Proteins are … an d….

Answer 4

Von Willebrand factor (vWF) & Collagen

Question 5

Facilitator Protein is ….

Answer 5

Thrombin

Question 6

Thrombin source is …

Answer 6

Platelets

Question 7

Mme tion platelets granule s???

Answer 7

1. α Granules

2. δ Granules

Question 8

How can the alpha granules in the platles make homustasis localized ?

Answer 8

Increase Platelet’s Surface Area

Question 9

vWF Dimers are formed in the …..which form

vWF Homomultimers in the …..

Answer 9

RER

Trans Golgi

Question 10

Von Willebrand Factor Synthesized by the ….cells and…..

Answer 10

Endothelium cells and

Megakaryocytes

Question 11

Multimerization is bounded together by ….

Answer 11

–S-S- bond formation [disulfide-bridge]

Question 12

What is the aa that signefecently found in the Von Willebrand Factor

Answer 12

Cysteine

Question 13

Von Willebrand Factor released in the blood by …% but the …% stored in the cells as …..

Answer 13

95%

5% as Weibel-Palade bodies

Question 14

vWF is Present in the

Answer 14

• Plasma,
• Platelet α-Granules
• Sub-endothelial connective tissue

Question 15

What is the ADAMTS13

Answer 15

Protease Removes UL vWF from the Plasma → Controls Thromboembolism

Question 16

GPIb and GPIIb work as …

Answer 16

Platelet Receptors

Question 17

Collagen help in ….

Answer 17

Localization

Question 18

FVIII is for …. mainly

Answer 18

Coagulation

Question 19

What is the main function of the Secondary Hemostasis Events

Answer 19

Reinforcement of Primary Plug by Fibrin

Question 20

Fibrin is Formed by the Process Called

Answer 20

Coagulation

Question 21

Coagulation is controlled by

Answer 21

Coagulation factors

Question 22

Coagulation Factors are Present as …. Plasma Proteins
1- active
2- inactive

Answer 22

InActive

Question 23

Most of the Coagulation Factors produced in the ….

Answer 23

Liver

Question 24

Liver Diseases may be Associated with…..

Answer 24

Bleeding Problems

Question 25

Some Coagulation Factors are Modified by Gamma Carboxylation Post-translationally. Why?

Answer 25

To increase the -ve charge bitch$D

Question 26

Mention Coagulation Factors are Modified by Gamma Carboxylation Post-translationally

Answer 26

- 2+7=9&10 | - protein C & S

Question 27

γ-Carboxylation is .... dependent reaction

Answer 27

Vitamin K

Question 28

Carboxylation is Inhibited by .....used as Anticoagulant Therapy 1- penicillen 2- amoxicillen 3- warafirn

Answer 28

3

Question 29

Gamma-Carboxylation Occurs at.. domin

Answer 29

GLA ; Sequence Rich in Glutamin Residues

Question 30

Extrinsic Pathway leads to ..... mainly A- initiation of coagulation B- amplification of coagulation

Answer 30

A

Question 31

Intrinsic Pathway leads to ... mainly A- initiation of coagulation B- amplification of coagulation

Answer 31

B

Question 32

Both Extrinsic Pathway and Intrinsic Pathway leads to ...

Answer 32

Formation of and Cross- linking of Fibrin Fibers around a Primary Plug →Hard Plug or Clot

Question 33

How can Kallikrein Amplifies the Intrinsic Pathway

Answer 33

Kallikrein, a Serine Protease that Causes Massive Activation of FXII [12]→Induction of the Intrinsic Pathway

Question 34

How can Kallikrein produced ?

Answer 34

Only Bound FXII produces Kallikrein (K) from a HMWK-PK Complex present in the circulation

Question 35

Extrinic pathway also called .... 1- in-vevo 2- out-vevo

Answer 35

1

Question 36

Tissue factor (FIII Expresses in the...,...,....

Answer 36

Sub-Endothelial | Smooth Muscle Cells, & Fibroblasts

Question 37

Tissue factor (FIII) main function is to

Answer 37

Serves as a high affinity Receptor for | the FVII