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Block 6 Week 1 Colt > L6 MHC Locus - Hudig > Flashcards

L6 MHC Locus - Hudig Flashcards

1
Q

What two proteins make up the MHC I ?

A

MHC I alpha and B2microglobulin

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2
Q

is B2microglobulin coded with MHC?

A

no, gene is outside MHC complex

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3
Q

What proteins make up the MHCII?

A

MHCII alpha and beta chains

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4
Q

Are CD proteins coded with MHC?

A

NOOPE, on a different chromosome

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5
Q

HOw many alleles of MHC does each person have?

A

2

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6
Q

is MHC inherited with crossing over?

A

NO

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7
Q

How many loci are there for MHCI? what are they called?

A

3; a, b, and c

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8
Q

How many loci are there for MHCII? What are they called?

A

3; DP, DQ, AND DR

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9
Q

what sets DR apart from DQ and DP?

A

It encodes two beta chains and one alpha chain instead of one each

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10
Q

Distinguish between multi-allelic and multigenic?

A 
multigenic= three genes come together to make MHC
multiallelic:= there are multiple variants of each of the three genes
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11
Q

which MHC I gene has the most alleles?

A

b

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12
Q

What is the pattern of MHC gene and allele expression?

A

both are codominant

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13
Q

How many different MHC I proteins will there be on a cell of a completely heterzygous person?

A

6

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14
Q

What cells would present with six types of MHCI?

A

all cells except APCs and RBCs

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15
Q

MHCI (blank) maximizes the antigenic peptide presentation in humans

A

allelic variation

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16
Q

Is it the way the proteasome degrades foreign peptides or MHCI construction that dictates antigen presentation?

A

MHCI construction, proteasome cuts the same protein up the same in everyone

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17
Q

Each memory CTL needs a match of the same peptide in the (same/any) MHC I (that fits into its TCR) to kill

A

SAME PEPTIDE IN SAME MHCI, NEEDS TO BE FUCKING IDENTICAL

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18
Q

What do you must have to test CTL anti-viral vaccines?

A

target cells of the SAME MHCI as the immune donor of the CTLs

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19
Q

Which MHC is inducible on endothelial cells during inflammation?

A

MHCII

20
Q

MHC class II allelic polymorphism means that some individuals will be (more/less) able to respond to some pathogens

A

LESS :(

21
Q

WHat cells lack both MHCI and II?

A

RBCs

22
Q

Neutrophils strongly express which MHC?

A

MHCI

23
Q

Which cells express both MHCI and MHCII?

A

APCs, macrophages, Bcells, and *occasionally T cells

24
Q

organ specific cells express MHCI or II?

A

MCHI

25
Q

What is relative risk?

A

is the incidence of the disease in individuals bearing the MHC locus/divided by the incidence in the population of individuals lacking the allele.

26
Q

What happens when preproinsulin binds to DR3, DR4, or DQ8 MHC proteins?

A

These MHC-peptides are selectively recognized by IDMM Type I immune patients. These anti-self T helpers could then support development of CTL anti-pancreatic beta cell killer cells.

27
Q

what is the order of importance when looking at barriers to transplantation?

A
  1. ABO BLOOD GROUP
  2. HLA class II
  3. HLA class I
  4. minor histocompatibility Ags
28
Q

What is an autograft?

A

tissue grafted from the same person OR between two genetically IDENTICAL people

29
Q

What is an allograft?

A

grafted between HLA and other loci ALLOGENIC individuals

30
Q

How quickly are allografts rejected?

A

within two weeks without immunosuppresion

31
Q

What is the result when transplant patients are MHC haplotype matched?

A

better survival and health

32
Q

Is there any way to have an organ transplant without immunosuppresion?

A

get your unfortunate twin to cough an organ up fer ya

33
Q

Can you still have graft rejection even with complete HLA matching?

A

yes

34
Q

Do T cells respond with greater frequency to foreign MHC molecules or to self MHC bearing an Ag?

A

Respond more to foreign MHC (1/100 tcells) while self mHC + Ag (1/1million t cells)

35
Q

MHCIII genes are non (blank)

A

allellic

36
Q

Haplotypes are linked sets of genes inherited as a (blank)

A

unit

37
Q

How many MHC haplotypes do you get from each parent?

A

one

38
Q

What bug produces super Ags?

A

staphylococci, staph aureus, including MRSA

39
Q

What makes something a super Ag?

A

they bind to a large number of t cells and trigger MASSIVE t cell response

40
Q

What about their binding pattern makes things super Ags?

A

they bind to the MHCII and TCR Vbeta receptor simultaneously

41
Q

Do superAgs bind in the MHCII binding groove?

A

no

42
Q

what are two diseases associated with super Ags?

A

toxic shock syndrome and food poisoning

43
Q

Can a super ag bind to any TCR Vbeta?

A

No, only specific ones

44
Q

What percent of T cells can a given super Ag bind to?

A

2-20%

45
Q

What does IL1 do systemically?

A

release of pyrogens and create a fever

46
Q

What happens after exposure to enterotoxins?

A

acute diarrhea

Block 6 Week 1 Colt (11 decks)

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