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P&T Block 5 Renal > L70 > Flashcards

Flashcards in L70 Deck (29)
1

Does too much or too little E put you at risk for risk for endometrial cancer?

Excess E - endo prolif
- Tamoxifen
- Obesity
- Diabetes
- No preg/early periods/late menopause

2

TESTQ: presenting symptom of endometrial cancer + follow up

Post-meno bleeding
Do biopsy, possible followed by D&C if need more tissue

3

What are the 2 types of endometrial hyperplasia?

Non-atypical = benign
Atypical = pre-cancerous

4

Is endometrial cancer surgically or clinically staged?

Surg

5

What is an endometrioid cancer?

Endometrial hyperplasia that still resembles the tissue of origin

6

Treat endometrial cancer for post-meno pt

Surgery - likely partial/full hysterectomy
Adj therapy of some kind

7

Treat endometrial cancer for a woman who still wants to have kids

+ Progesterone (PO or IUD) - only for low grade/stage cancers

8

What are some of the different types of uterine sarcomas?

MMMT = carcinosarcoma
Leio-myo-sarcoma
Overall sarcomas = rarer = more aggressive

9

Anti-step: is grade of stage the most important prognostic factor for endometrial cancer?

Grade... lol its actually stage for step

10

You know what strains of HPV go in the cervical cancer vaccine, but what part of the virus is used to make it?

Empty viral capsid - makes sense! You just need to recognize the outside

11

What are the 2 parts of cervical cancer screening?

1. Pap smear
2. If see, ASC-US do HPV testing

12

What are the next steps if an HPV test comes back positive?

Colposcopy determines abnormal areas for biopsy

13

TESTQ: presentation of invasive cervical carcinoma

Bleeding after sex

14

Most common types of invasive cervical cancer

SCC - from exocervix
Adenocarcinoma - from endocervix

15

Is cervical cancer staged surgically or clinically?

Clinically
Look for LOCAL spread: involved the vagina? Pelvic side walls? Bladder/ureters?

16

Treat cervical cancer

Based on stage
Surg + rad +/- chemo

17

What are the 3 categories of endometrial cancers?

1. Epithelial cell cancer - most
2. Stromal cell cancer = granulosa or Leydig/Sertoli cells
3. Germ cell tumors

18

How does ovulation play into your risk of ovarian cancer?

More ovulation cycles = higher risk
Preg, PO birth control, breast feeding all protective

19

2 genetic risk factors for ovarian cancer

**BRCA 1/2**
HNPCC (Lynch syndrome)

20

Ovarian cancer presenting symptoms

Non-specific!!!
Bloating + fuller ab size

21

Marker for endometrial cancer that you can test for

CA-125 - not screening
For treatment response and recurrance

22

What might ovarian mets look like

Seed the abdomen
1. Ascities
2. Omental caking = thickening of omental fat

23

Is ovarian cancer staged clinically or surgically?

Surg - examine regional LN specimens

24

Treat high vs low stage ovarian cancer

Low - surg only
High - surg + adj chemo
Chemo = intraperitoneal carboplatin/taxol

25

Are you worried about ovarian cancer recurrence?

YEP - even if you go into remission, you'll relapse at some point

26

Where does endo vs cervical vs ovarian cancer met

Endo to LNs
Cervix locally
Ovarian into peritoneum

27

What is the tumor marker for a dysgerminoma? (ovarian germ cell tumor)

LDH

28

What is the tumor marker for a yolk sac tumor? (ovarian germ cell tumor)

AFP

29

What is the tumor marker for choriocarcinoma? (ovarian germ cell tumor)

HCG