L9-10 Pharmacokinetics Flashcards Preview

BMS242 Core Phys Pharm > L9-10 Pharmacokinetics > Flashcards

Flashcards in L9-10 Pharmacokinetics Deck (107)
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1

Drug effects depend on

Mechanism of action
Physiochemical properties of drugs
Concentration

2

What are the physiochemical properties of drugs

Affinity
Efficacy
Potency

3

What are the four elements which affect drug concentration

Absorption
Distribution
Metabolism
Excretion

4

Bulk flow of drug uses what

The CV system

5

4 methods of drug movement across cell membranes

Simple diffusion
Diffusion through aqauporins
Carrier
Pinocytosis

6

What are the physiochemical properties of the drugs

Lipid solubility
Diffusivity

7

What constant can be used to quantify lipid solubility

Partition coefficient

8

What constant can be used to quantify diffusivity

Diffusion coefficient

9

What type of molecules dissolve freely in lipids and penetrate cell membranes freely

Lipid soluble

10

What would the effect of using a lipid soluble molecule on rate of absoption from gut be

Increase

11

What would the effect of using a lipid soluble molecule on penetration of the brain and other tissues

Increase

12

What would the effect of using a lipid soluble molecule on renal elimination

Increase

13

What is is one of the most important determinants for pharmacokinetic characteristics of the drug

Lipid solubility

14

Describe intravenous administration
When might it be used

Injection straight into the plasma
In emergencies

15

What drugs may need to be administered intra muscularly

Drugs that would be at high risk of being metabolised in the gut

16

What types of drugs may be at high risk of being destroyed in the gut

Peptides

17

Give an example of a peptide drug

Insulin

18

What does intrathecal inject into

Direct into the CSF

19

Give an example of when intrathecal admin. may be used

During labour to administer local anasthetics

20

Define bioavailability

How much of the injected drug will make it into the plasma

21

What must be overcome in the stomach

Low pH

22

What is the portal system, what is the danger if drugs enter

Involving the liver
Drugs would be metabolised by the liver

23

What can be controlled with a drug in tablet form

The rate at which the active form of the drug is liberated from the tablet

24

When may the oral route be unsuitable

When vomitting
GI problems - ulceration
Young children may find it hard to swallow

25

If the drug target was the GI tract what would be the favoured method of administration

Rectal route

26

What is usually the difference between cheaper and more expensive over the counter drugs

Particle size - tends to be larger with cheaper drugs

27

What is percutaneous administration

Absoprtion through the skin

28

Example of a drug that is adminstered percutaneously

Nicotine via patches

29

What is the problem with percutaneous administration

Skin is highly impermeable
Drug would need to have a high lipid solubility

30

What would the targets of drugs be that were adminsistered percutaneously

Nuclear receptors