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Flashcards in WHOLE MODULE Deck (375)
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1

What is the relationship between Kd and DR

Inverse

2

What does an agonist have to be able to do in order to be classed as a full agonist

Induce the max repsonse of the tissue

3

What can be said about the ion turnover of facilitated transport proteins

It is high
10^2 - 10^3 ions / s

4

what is the name of the transporter which allows Na to enter TAL cells

NKCC2

5

What type of cells are increase in rheu arth patients

Th1 cells

6

Does Kd always equal EC50

No

7

ADVANTAGE/DISADVANTAGE
H3 OR I(125)

Difficult to incorporate ligand fue to high mass

Disad I 125

8

What is occupancy dependent on

Drug concentration

9

What is meant by aspiring being a suicide inhibitor

Permanently binds to XOZ

10

ADVANTAGE/DISADVANTAGE
H3 OR I(125)

Biological act of the ligand can be reduced

Disad I 125

11

Act of macrophages as a result of autoimmune resp leads to synth of which two pro inf mediators

Interleukin-1 (IL-1) and tumor necrosis factor a (TNF-A)

12

What occurs when calcineurin is activated

Activation leads to removal of phosphate groups and act of TF NFKB that promotes transcription of pro-inflam chem/cytokines

13

NAPQI toxic intermediate A or P

Paracetamol

14

What is meant by physiological antagonism

When two or more drugs interact with opposing actions - or act through different transduction machinery

15

What is the difference between the nernst and goldman equations

Nernst used to calc eqbm pot wherease goldman used to calculate the membrane potential

16

Define specificity

the attribute that a drug will preferentially bind to one type of receptor over another

17

What can usually be said of the metabolism of a drug which is rapidly absorbed from the drug

Metabolism will be fast

18

Describe how allosteric modifications aid in acid extrusion

Protons other than the one being transported bind to the NHE protein and cause a conformational change that results in an increased rate of transport at higher protein concentrations

19

Give examples of medications given directly to the skin

Nicotine patches, chronic pain treatments such as fentinon

20

Who developed the patch clamp technique

Nehr and Sakman

21

ADVANTAGE/DISADVANTAGE
H3 OR I(125)

High specific activities can be obtained

Ad H3

22

Would a drug with a higher Kd be more or less potent

Less

23

How can we classify facilitated transport proteins

Uniporters, symporters and antiporters

24

What is the benefit of biologicals in treatment of autoimmune disease and how can this cause problems

More longer lasting (longer half life) and fewer off site effects, but can dampen down the immune system so more susceptible to infection

25

How many TM domains of VGKC

6

26

How many transmembrane domains does a GPCR have

7

27

Where is AE1 predominantly found - what is its main role

Red blood cells
Creates the Cl-/Hamberger shift

28

Explain how particle size influences a drugs effectiveness

Larger particle sizes as are found in non-branded medication will more often be metabolised so less of that drug will have an effect. Smaller particles are more liekly to enter the blood stream

29

What prevents an acid from being absorbed into cells once it is dissociated

Acid group will have a negative charge and the cell is also negatively charged so will be unable to cross the membrane

30

What is the Cl/HCO3 exchanger primarily involved with

Involved in acid loading