L5-8 Receptor Theory Flashcards Preview

BMS242 Core Phys Pharm > L5-8 Receptor Theory > Flashcards

Flashcards in L5-8 Receptor Theory Deck (156)
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1

What is the major target of drugs

Proteins

2

What is a target of a select group of drugs, what type of drugs target this

DNA
Chemotherapy drugs

3

Define a receptor

Proteins whose function it is to recognise and respond to endogenous chemical signals

4

What are some examples of protein targets of drugs

Receptors
Enzymes
Transporters and Carriers
Ion channels

5

Define a drug target

Other macro molecules which drugs interact with in order to produce their effects

6

Receptors are classified by

Strucuture, pharmacology and signalling

7

Receptors show _______ in the classes of drugs which they recognise

Specificity

8

Are drugs 100% efficient

No, no drug is 100% specific

9

What arises as a result of a loss of receptors

Disease

10

Location of ligand gated ion channels

Membrane

11

How many tm domains in ligand gated ion channels

Variable

12

Where is the c' term in ligand gated ion channels

Extracellular

13

Where is the n' term in ligand gated ion channels

EC

14

What is the effector for a ligand gated ion channels

Ion channel

15

What type of coupling involved in ligand gated ion channels

Direct

16

Structure of ligand gated ion channels

Oligomeric assembly of subunits around a central pore

17

Location of GPCRs

Membrane

18

How many TM domains in GPCRs

7

19

Where is the c' term in GPCRs

IC

20

What is the effector for GPCRs

Channel or enzyme

21

Where is the n' term for GPCRS

EC

22

Coupling GPCRs

Via a G-protein

23

Structure of a GPCR

Mon/oligomeric assemblt of 7 TM helicies with an IC G-protein coupling domain

24

Location of kinase-linked receptors

Membrane

25

How many TM domaiins kinase-linked receptors

1

26

Where is c' term kinase-linked receptors

IC (catalytic domain)

27

Where is the n' term. kinase-linked receptors

EC (binding ligand domain)

28

Effector for kinase-linked receptors

Protein kinases

29

Coupling in kinase-linked receptors

Direct

30

Structure of kinase-linked receptors

Single Tm domain linked to EC receptor domain and IC catlytic domain