Lab Dermatopathology Class Flashcards Preview

MSK Week 1 > Lab Dermatopathology Class > Flashcards

Flashcards in Lab Dermatopathology Class Deck (15)
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1
Q

Dermatoses

A

refers to diseases of the integumentary system specifically affecting the skin, nails, hair, and glands

2
Q

Basis of Urticaria

A

Mast cells degranulate resulting in microvascular hyperpermeability. Clinically presents with wheals which are usually puritic

3
Q

Lichen Planus

A

disease of skin and mucous membranes that resembles lichen, ii. The most common CUTANEOUS presentation is as a well-defined area of purple-colored, itchy, flat-topped papules with interspersed lacy white lines

4
Q

What type of hypersensitivity is contact dermatitis?

A

Type IV - CD4+ TH1 cells secrete cytokines that stimulate inflammation and activate phagocytes, leading to tissue injury

5
Q

Acute form of contact dermatitis

A

diffuse erythema, edema, oozing, and crusting with formations of vesicles and bulla

6
Q

Chronic form of contact dermatitis

A

Scaling, thickening skin

7
Q

What hypersensitivity reaction is Pemphigus Vulgaris?

A

Type 2

8
Q

Pemphigus Vulgaris

A

autoantibodies react against cell adhesion molecules causing acantholysis (loss of intercellular connections) of the epidermis and different mucosae.

9
Q

Symptoms of Pemphigus Vulgaris

A

PV usually starts as oral lesions that make it difficult to eat (odynophagia). This may lead to noticeable weight
loss. Oral lesions are followed by generalized bullae 6-12 months later

10
Q

Nikolsky’s sign?

A

Separation of the epidermis upon manual stretching of the skin. Lifting the skin results in separation from the dermis

11
Q
  1. How does the mechanism of blister formation in bullous pemphigoid differ from pemphigus vulgaris?
A

In bullous pemphigoid the antibody reaction is against hemidesmosomes rather than desmosomes; and it targets skin rather than mucosa

12
Q

What condition involves CD+8 T cell toxicity along with keratinocyte injury?

A

Erythema Multiforme

13
Q

Guttate

A

Drop shaped

14
Q

Parakeratosis

A

keratinized cells with abnormal retention of nuclei at the stratum corneum

15
Q

Acanthosis

A

Thickening of the epidermis