Lab Dermatopathology Class Flashcards Preview

MSK Week 1 > Lab Dermatopathology Class > Flashcards

Flashcards in Lab Dermatopathology Class Deck (15):
1

Dermatoses

refers to diseases of the integumentary system specifically affecting the skin, nails, hair, and glands

2

Basis of Urticaria

Mast cells degranulate resulting in microvascular hyperpermeability. Clinically presents with wheals which are usually puritic

3

Lichen Planus

disease of skin and mucous membranes that resembles lichen, ii. The most common CUTANEOUS presentation is as a well-defined area of purple-colored, itchy, flat-topped papules with interspersed lacy white lines

4

What type of hypersensitivity is contact dermatitis?

Type IV - CD4+ TH1 cells secrete cytokines that stimulate inflammation and activate phagocytes, leading to tissue injury

5

Acute form of contact dermatitis

diffuse erythema, edema, oozing, and crusting with formations of vesicles and bulla

6

Chronic form of contact dermatitis

Scaling, thickening skin

7

What hypersensitivity reaction is Pemphigus Vulgaris?

Type 2

8

Pemphigus Vulgaris

autoantibodies react against cell adhesion molecules causing acantholysis (loss of intercellular connections) of the epidermis and different mucosae.

9

Symptoms of Pemphigus Vulgaris

PV usually starts as oral lesions that make it difficult to eat (odynophagia). This may lead to noticeable weight
loss. Oral lesions are followed by generalized bullae 6-12 months later

10

Nikolsky's sign?

Separation of the epidermis upon manual stretching of the skin. Lifting the skin results in separation from the dermis

11

5. How does the mechanism of blister formation in bullous pemphigoid differ from pemphigus vulgaris?

In bullous pemphigoid the antibody reaction is against hemidesmosomes rather than desmosomes; and it targets skin rather than mucosa

12

What condition involves CD+8 T cell toxicity along with keratinocyte injury?

Erythema Multiforme

13

Guttate

Drop shaped

14

Parakeratosis

keratinized cells with abnormal retention of nuclei at the stratum corneum

15

Acanthosis

Thickening of the epidermis