lec2: Red blood corpuscles

Question 1

RBCs Formed in the………………….

Answer 1

bone marrow

Question 2

Lifespan of RBCs………………

Answer 2

120 days

Question 3

the most abundant cells

in the blood…

Answer 3

biconcave red blood cells

Question 4

Number of RBCs
………….. in females
………………. in males

Answer 4

4-5 million/mm3 in females

5-6 million/mm3 in males

Question 5

RBCs Higher in………..and…………

Answer 5

male and newly born

Question 6

Red blood cell cytoplasm contain………..water………… hemoglobin

Answer 6

60% water

34% hemoglobin

Question 7

The average normal hemoglobin

concentration in blood is …………..

Answer 7

15 gm/dl

Question 8

The normal hemoglobin

concentration in men , women

Answer 8

15-17 g/dL in men

13-15 g/dL in women

Question 9

RBCs membrane is Concave to
…………………
.
and ………………..

Answer 9

increase surface
area available
for gas exchange
and diffusion

Question 10

The integral proteins

Band 3 ………….

Answer 10

the negative ion

exchanger

Question 11

The linker protein………………

Answer 11

ankyrin

Question 12

The cytoskeleton protein

…………

Answer 12

spectrin

Question 13

Genetic mutations in ankyrin, spectrin, proteins

leads to………………..

Answer 13

hereditary spherocytosis

Question 14

The ability of the red blood
cells (8 microns) to change their
shape to cross through the
narrow capillaries (3 microns)

Answer 14

Plasticity

Question 15

Semipermeable allow
…………….. to pass
easily in or out of RBC,
and but not…………………..

Answer 15

negative ions

positive ions

Question 16

Red blood cell membrane contains

…………. to ……………..

Answer 16

Na-K ATPase pump to maintain cell

volume

Question 17

The human red cells
membranes contain a
………………

Answer 17

variety of blood

group antigens

Question 18

……………………
differ in their terminal
sugar

Answer 18

complex

oligosaccharides

Question 19

Why it is important to keep Hemoglobin

(Hb) inside RBCs?

Answer 19

To avoid increase in:
➢ Blood viscosity, which may increase work of the
heart
➢ Osmotic pressure, which interfere with filtration at
capillaries .

To avoid Hb loss in
urine where it will react 
with HCL forming acid 
haematin
that block renal tubules 
leading to renal failure

Question 20

What is Hemoglobin

Answer 20

The red, oxygencarrying pigment in

human red blood cells

Question 21

Hemoglobin contains ………… subunits

Answer 21

four subunits

Question 22

Each subunit in Hemoglobin 2 parts
……………….. moiety
conjugated to a
……………………

Answer 22

heme , polypeptide

Question 23

WHY 98% of the O2
carried 
in the blood is bound 
to Hb in the form of 
oxyhemoglobin????

Answer 23

Because O2 is poorly soluble in the plasma

Question 24

Hemoglobin binds O2 to form ……………..

Answer 24

oxyhemoglobin

Question 25

Hemoglobin binds CO2 to form ...........................

Answer 25

carbaminohemoglobin

Question 26

CO2 binds to................of hemoglobin

Answer 26

amino group

Question 27

WHY Hemoglobin acts as a | buffer in the blood??

Answer 27

as it contains many amino acids as histidine

Question 28

The fetus has ...................

Answer 28

Hemoglobin F (α2 & 2)

Question 29

Fetal Hb is replaced by adult hemoglobin ................. after birth.

Answer 29

2-3 months

Question 30

Fetal Hb facilitates O2 transport across the | placenta due?

Answer 30

It has a higher oxygen affinity than HbA

Question 31

RBCs is less in........ than in.........., but higher in .............

Answer 31

children ,, adult ,newly born infants,

Question 32

Hemoglobin forms .......... of RBCs

Answer 32

34%

Question 33

Hemoglobin carries .......... of the oxygen, carbon dioxide | and acts as an ............

Answer 33

98% | important buffer

Question 34

What is the normal red blood cells count, hematocrit value, Hb level ?

Answer 34

 Male: 5-6 million/mm3, 45-47%, 14-16 gm% |  Female: 4-5 million/mm3, 43-45%, 12-14 gm%