Lecture 09_Fall Flashcards Preview

Pharmacology I _ Exam 3 Material > Lecture 09_Fall > Flashcards

Flashcards in Lecture 09_Fall Deck (30):
1

Identify the Adrenergic Agonist:

-Direct alpha 1 agonist ("pure-a")
-peripheral vasoconstriction
-Reflex Bradycardia
-Increased coronary blood flow

Phenlephrine (Neo-Synephrine)

2

Identify the Adrenergic Agonist:

-Direct adrenergic agonist
-B1->inc HR, contractility
-B2-> bronchodilation
-A1-> dec. splenic/renal blood flow & inc. coronary/cerebral perfusion pressure

Epi

3

Identify the Adrenergic Agonista:

-non-catecholamine sympathomimetic
-Indirect > Direct
-Causes NE release -> rapid tachyphylaxis
-Mild direct Beta action -> inc HR

Ephedrine

4

Identify the Adrenergic Agonist:

-Direct alpha 1 stimulation
-Intense arterial and venous vasoconstriction
-end-organ ischemia/necrosis
-Pulmonary vasoconstriction

NE

5

Identify the Adrenergic Agonist:

-Dose related agonist to all adrenergic receptors (DA > B > A)
-Good for pedi
-causes tachy

Dopamine

6

Identify the Adrenergic Agonist:

-Highly potent B1 and B2 agonist
-Incr HR & contractility
-Bronchodilator
-Decrease in SVR due to peripheral vasodilation, but overall effect is inc SBP and dec DBP

Isoproterenol

7

Identify the Adrenergic Agonist:

-Selective B1 agonist -> inc CO due to contractility
-INOTROPE
-Coronary vasodilation
-Weak B2 activity -> slight Inc HR

Dobutamine

8

Identify the Adrenergic Agonist:

-Selective Phosphodiesterase (PDE) Inhibitor
-INODILATOR
-Effective pulmonary vasodilator
-Signif effect on SVR -> HYPOTENSION

Milrinone (Primacor)

9

Identify the Adrenergic Agonist:

-Selective DA1 receptor agonist
-Inc renal blood flow -> diuresis
-Dec PVR -> reflex tachycardia

Fenoldopam

10

Identify the Adrenergic Agonist:

-Selective A2 agonist (A2:A1 =220:1)
-used to treat hypertension
-Not commonly used in IV
-Sedative
-Adjunct for analgesia: add to LAs or opioids for RA
-Withdrawal syndrome: hypertensive crisis

Clonidine

11

Identify the Adrenergic Agonist:

-more highly selective A2 agonist than Clonidine
-(A2:A1 = 1620:1)
-used primarily for sedation
-used to treat hypertension

Dexmedetomidine (Precidex)

12

Identify the Adrenergic Agonist:

-Non-adrenergic sympathomimetic
-Activation of smooth muscle V1 receptors
-Exogenous version of ADH
-Effective vasoconstrictor (binds to vascular smooth muscle)
-May preserve mesenteric perfusion better than NE
-Extravasation -> tissue necrosis

Vasopressin

13

Which adrenergic agonist has effects similar to epi?

Ephedrine

14

Which adrenergic agonist is the drug of choice in OB because it is thought to preserve uterine blood flow better than direct A1 agonsists?

Ephedrine

15

Does ephedrine cause greater arterial or venous vasoconstriction?

Venoconstriction > arteriolar constriction

->Redistribution of blood centrally
->improved venous return (preload)

16

___ is used to treat anaphylaxis and v-fib.

Epi

17

How does the duration of action of ephedrine compare to that of epi?

ephedrine last 10x longer than epi

18

___ is used in TX of diabetes insipidus.

Vasopressin

diabetes insipidus = lack of ADH secretion

19

Risks associated with the use of Epi include ___, ___ and ____.

Risks:
-cerebral hemorrhage
-coronary ischemia
-ventricular dysrhythmia

20

Withdrawal of ____ could lead to hypertensive crisis.

clonidine

21

T or F. Ephedrine may have anti-emetic properties.

TRUE

22

___ can be used to support BP in septic shock, cardiac arrest, post-CPB vasoplegia, and interaction between ACE-I and general anesthesia.

Vasopressin

23

In addition to its sedative effects, side effects of clonidine include ___, ___, and ___.

bradycardia, hypotension, dry mouth

24

___ is effective for treating post-op shivering.

Clonidine

25

Identify the adrenergic agonist:

-May increase cardiac O2 requirements as well as decrease myocardial perfusion
- Also, coronary artery dilation may lead to coronary steal

Isoproterenol (Isuprel)

26

T or F. Milrinone is an effective pulmonary vasodilator.

TRUE

27

____ is used to Inc HR in presence of Heart block - maintains HR until pacemaker can be placed

Isoproterenol (Isuprel)

28

What are the "Low," "Med" and "High" dose ranges of Dopamine and which receptor is associated with each?

Low Dose <2 mcg/kg/min = DA receptor

Med Dose 2-10 mcg/kg/min = B1 receptor

High Dose 10-20 mcg/kg/min = A1 receptor

29

___ is not a good 1st-line treatment for cardiogenic shock but can be used to treat refractory hypotension (shock, sepsis)

NE

30

T or F. NE should only be given thru central access - not a PIV b/c extravasation->tissue necrosis.

TRUE