Lecture 10_Fall Flashcards Preview

Pharmacology I _ Exam 3 Material > Lecture 10_Fall > Flashcards

Flashcards in Lecture 10_Fall Deck (24):
1

Name 2 non selective Alpha receptor antagonists.

Phentolamine and Phenoxybenzamine

2

T or F A2 receptor blockade leads to tachycardia

True. It eliminates negative feedback which leads to more NE release.

3

___ and ____ are almost exclusively for the mgmt of pheochromocytomas

Phentolamine and Phenoxybenzamine

4

____ reversibly binds to alpha receptors, causes vasodilation, is a treatment for NE extravasation and is a reversal of LA injection

Phentolamine

5

___ irreversibly binds to alpha receptors and an overdose of this drug is treated with NE

Phenoxybenzamine

6

___ is a non selective beta antagonist that has been associated with rebound HTN, tachycardia and angina when patients stop taking it due to the up-regulation of beta receptors

Propranolol (Inderal)

7

What type of beta blocker should be used in pts w/ reactive airway disease?

B1 selective antagonist

8

____ is an ultra short acting B1 selective antagonist.

Esmolol (BreviBloc)

9

____ is the common drug of choice for intraop HTN because decreases PVR and renin, and causes some decrease in HR.

Labetalol

10

The main indication for use of which beta blocker is treatment of a thyroid storm (thyrotoxicosis) or pheochromocytomas?

Propranolol (Inderal)

11

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Atenolol

B1 selective antagonist

12

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Labetalol

Mixed antagonist (A1 B1 and B2)

13

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Carvedilol.

B1 selective antagonist

14

This non-selective beta blocker is no longer commonly used because of its following side effects: bronchospasm, CHF, bradycardia and AV heart block.

Propranolol (Inderal)

15

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Metoprolol

B1 selective antagonist

16

This adrenergic antagonist's short duration of action is due to its rapid redistribution (2 min) and ester hydrolysis (9 min).

Esmolol (BreviBloc)

17

T or F. Labetalol causes reflex tachycardia.

False. It is a mixed antagonist with alpha and beta receptor antagonism.

18

___ is a good choice for preventing tachycardia and hypertension during intubation and emergence.

Esmolol

19

What are 3 side effects associated with alpha-1 receptor blockade?

Side effects: hypotension, orthostatic hypotension, tachycardia

20

Phenylephrine will have what effect on a patient who has taken Phenoxybenzamine?

No effect. Phenylephrine response is completely blocked

21

NE will have what effect on a patient who has taken Phenoxybenzamine?

Norepinephrine response: tachycardia due to B1 activation

22

Epi will have what effect on a patient who has taken Phenoxybenzamine?

Epinephrine response: tachycardia and severe hypotension due to B2-mediated vasodilation

23

How does an alpha-2 receptor blockade work and what does it cause?

A2-receptor blockade -> eliminates negative feedback -> more NE release -> tachycardia

24

When treating a pheochromocytoma, which should you do first and which should you do second...alpha block vs beta block.

A-blockade before B-blockade