Lecture 1

Question 1

pharmacokinetics

Answer 1

-study of ADME

Question 2

Major elimination pathways

Answer 2

-hepatic metabolism
-renal excretion

Question 3

IV bolus

Answer 3

-rapid injection
-ENTIRE dose enters circulation immediately
-skip absorption

Question 4

One compartment model

Answer 4

-assume body acts as one compartment
-drug in rapid equilibrium between blood compartment and tissue compartment
=change in plasma levels = change in tissue levels

Question 5

multi-compartment model

Answer 5

-one compartment not enough to explain distribution

Question 6

First order elimination

Answer 6

-elimination rate is proportional to concentration of drug

Question 7

First order equation

Answer 7

dA = -k * [A]

A=A0(e^(-Kel*t))

Question 8

Kel

Answer 8

-drug specific property
-rate constant

Question 9

Volume of distribution (Vd)

Answer 9

-constant relating to concentration

A = Vd * [A]

Question 10

Dose after Iv injection

Answer 10

dose = Vd * [A0]

Question 11

100 mg of Drug X administered via IV bolus. What would be the typically
expected drug X concentration in the blood taken right after the IV dose?

Answer 11

LESS than 20 mg/L

100mg/5mL
blood volume
-most drugs distribute immediately

Question 12

Lipophilic compounds

Answer 12

-better distribution
-lower [A0] given a dose

Question 13

hydrophilic compounds

Answer 13

-do not cross bilayers readily
-higher [A0] given a dose