Multiple Dosing

Question 1

Infusion vs multiple dosing

Answer 1

-infusion is whole dose over time period
-multiple dosing is fractions of dose given at certain time intervals

Question 2

Graph of multiple dosing

Answer 2

-several jagged peaks

Question 3

Large Accumulation Index (Rac) means

Answer 3

-greater concentration at Css than from first dose

Question 4

accumulation depends on

Answer 4

tau

Question 5

larger tau

Answer 5

-less frequent dosing
-gives smaller accumulation index (more time for drug to be eliminated)
-leads to greater fluctuation
-lower Css,ave
-same time to reach new steady state (based on half life) 3.3t1/2

Question 6

Fluctuation depends on

Answer 6

Tau

Question 7

Css ave of drug administered as same amt of dose per unit time

Answer 7

-same

Question 8

Average concentration (Css.ave)

Answer 8

-concentration that gives AUCss0-T when maintained for T