Lecture 1 Flashcards

(112 cards)

1
Q

cerebrum

A

(motor cortex, premotor cortex, sensory cortex) main portion of the brain occupying the upper part of the cranial cavity. The cerebral cortex is a thin layer of gray matter that is folded into gyri with about 2/3 of the matter buried into the depths of fissures; it reaches its development in man and is responsible for higher mental functions, movement, visceral functions, perception, behavioral reactions, and for the association and integration of these functions. Major areas of concern for movement are the motor cortex and sensory cortex

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2
Q

Motor cortex

A

consists of primary motor cortex and the premotor cortex; the motor cortex lies anterior to the central sulcus and occupies approximately the posterior third of the frontal lobes.

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3
Q

premotor cortex

A

lies anterior to the motor cortex; causes general patterns of movement involving groups of muscles that perform specific tasks and along with the basal ganglia and thalamus , the premotor cortex is involved the unconscious fine tuning of muscle activity required for highly-skilled movements. The extrapyramidal system originates in the premotor cortex.

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4
Q

sensory cortex

A

lies posterior to the central sulcus and relays info into the motor cortex for control of motor activities.

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5
Q

basil ganglia

A

collection or cuter of cell bodies that make-up the central gray matter of the cerebral hemispheres. The basal ganglia functions in muscle tone, control of mvmt. Lesions in this area may result in jerky, rapid involuntary mvmt and/or paralysis depending on nuclei damaged.

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6
Q

thalamus

A

acts primarily as a relay station of sensory input as well as interpretation of some sensory input, such as pain, temp, crude pressure, and touch

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7
Q

cerebellum

A

hindbrain, concerned with coordination of mvmt

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8
Q

brainstem

A

composed of medulla oblongata, pons, and midbrain; located superior to spinal cord

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9
Q

medulla oblongata

A

controls heart rate, blood flow, equilibrium, swallowing and salivation, and reparation along with pons; contains all ascending as well as descending tracts that communicate between the spinal cord and various parts of the brain as well as the decussation of pyramids.

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10
Q

pons

A

acts as a bridge between the spinal cord and brain as well as between various parts of the brain; controls respiration along with the medulla oblongata; also involved in facial/neck sensations and the regulation of facial expressions, eye mvmt, taste, salivation, and equilibrium

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11
Q

midbrain

A

connects to pons to lower diencephalon (hypothalamus and thalamus) and spinal cord sensory fibers to diencephalon; conveys sensations of touch, proprioception, and vibrations to the thalamus; also, it is involved in the regulation of eye movement, pupil size, and lens shape.

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12
Q

pyramidal system

A

neural impulses originate in the motor cortex of the brain; the motor tracts synapse w motor neurons in the anterior gray horn of the spinal cord and innervate those muscles involved in specific movements .Of the pyramidal motor track, 90% cross-over at the decussation of the pyramids and 10% are ipsilateral (descend along the same side/do no cross over). Early training of motor

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13
Q

extrapyramidal

A

neural impulses originate in the premotor cortex of the cerebral cortex; the neural tracts do not synapse directly with motor neurons but go thru the motor nuclei, pons, and cerebellum. *involved in general movement patters and highly skilled movements

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14
Q

sensory receptors

A

(muscle spindles, golgi tendon organs, joint receptors) provide feedback to the central nervous system. Proprioceptors in general sense position, length, tension, pressure, and temperature in a muscle and hence, regulate rate of change in length as well as facilitating kinesthetic awareness.

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15
Q

muscle spindles

A

proprioceptors located in intrafusal muscle fibers which lie parallel to the extrafusal (normal) muscle fibers.

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16
Q

golgi tendon organs

A

proprioceptors located in muscles at their junctions with tendons and in ligaments of joints. Act as a protective mechanism. facilitate the recruitment of additional motor units in order to maintain force production. Also appear to help equalize the contractile forces of separate muscle fibers.

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17
Q

joint receptors

A

(end bulbs of Krause, pacinian corpuscles, and Ruffini corpuscles) found in tendons, ligaments, bone, muscle, and joint capsules where they provide sensory info regarding going angle, acceleration at the joint, and the degree of deformation brought about by pressure.

** greatly contribute to kinesthetic awareness as they provide info regarding body awareness.

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18
Q

limbic system

A

(hypothalamus and related structures) provides input to the motor cortex regarding motivation drives and needs

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19
Q

ipsilateral

A

on the same side

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20
Q

proprioceptors

A

sensory receptor that receives stimuli from within the body, especially one that responds to position and movement

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21
Q

intrafusal fibers (component of muscle spindle apparatus)

A

muscle fibers within a muscle spindle which run parallel to the extrafusal muscle fibers involved in gross muscular contraction.

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22
Q

gamma motor neurons (component of muscle spindle fiber)

A

activate intrafusal muscle fiber

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23
Q

annulospiral endings (component of muscle spindle apparatus)

A

sensory receptors that detect the length or stretch on the intrafusal muscle fibers

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24
Q

sensory afferent neurons (component of muscle spindle apparatus)

A

carries info back to spinal cord

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25
3 functions of muscle spindles
1) sense length of fibers 2) reflex contraction 3) coactivation
26
motor unit
motor neuron and all the muscle fibers that it innervates
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extrafusal muscle fibers
innervated by alpha motor neurons, and generate tension by contracting, allowing skeletal movement.
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physiological characteristics of a motor neuron
FT: large cell bodies, thicker axons, require high levels of neural stimulation in order to depolarize and propagate neural impulses. propagate neural impulses faster than ST motor units. used less frequently. used during maximal effort (high intensity) slow speeds, high intensity fast speeds of mvmt, low intensity, long duration tasks when ST motor units become fatigued ST: smaller cell bodies, thinner axons. require lower levels of neural stimulation in order to depolarize and propagate neural impulses. propagate neural impulses slower than FT motor units. used more frequently. used during high intensity, slow movements and during low intensity, long duration tasks. - motor units w smaller bodies are generally recruited first followed by motor units whose neurons have larger cell body (FT).
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neuron
nerve cell
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soma
cell body of a neuron
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axon
process of a neuron that carries impulses away from the cell body
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dendrite
portion of a neuron that carries impulses away from the cell body
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Schwann cell
responsible for producing myelin
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node of Ranvier
portion of myelinated (lipid and protein covering) axon which is not covered by myelin sheath; important for saltatory conduction as impulse "jumps" from one node of Ranvier to the next allowing for fast nerve impulse conduction.
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synapse
point of contact where nerve impulses are transmitted from one neuron to another
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pre-synaptic membrane
membrane proximal to a synapse
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post-synaptic membrane
membrane distal to synapse
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synaptic cleft
gap between pre and post synaptic membranes
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synaptic vesicle
vesicles in the axon terminal where neurotransmitters (Ach) are stored
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neurotransmitters
(ACh and gamma amino butyric acid) chemical substance that is released from the pre synaptic axon terminal; diffuse across the synaptic cleft and initiates an action potential in the post-synaptic membrane and the influx of Na++ stimulates an electrical current
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epimysium
connective tissue surrounding a muscle; connects into tendon at the origin insertion of the muscle
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perimysium
connective tissue surrounding a fasciculous or a group of muscle fibers
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endomysium
connective tissue surrounding a muscle cell or fiber
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sarcolemma
muscle cell membrane
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sarcoplasm
cytoplasm of muscle cell; site of anaerobic metabolism; contains myoglobin, fat, glycogen, phosphocreatine, ATP, mitochondria (site of cellular oxidation or aerobic metabolism; powerhouse of a cell), and hundreds of myofibrils (threadlike protein strands).
46
mitochondria
site of cellular oxidation or aerobic metabolism; powerhouse of a cell
47
myofibril
threadlike protein strands. within myofibrils are sarcomeres
48
sarcomere
functional or contractional units of the muscle cell. within sarcomere are actin (thin) and myosin (thick)
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actin
thin protein myofilaments
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myosin
thick protein myofilaments. each myosin myofilament is surrounded by 6 or more actin myofilaments
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cross bridge of S1 head of myosin
extensions on myosin
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tropomyosin
Attached or surrounding the actin myofilaments. long thin molecules that lie on the surface of the actin strand
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troponin
globular molecules. Tropomyosin molecules are embedded here.
54
Z line
anchored to the sarcolemma where they (1) lend stability to sarcomere, (2) keep actin myofilaments in line (actin are attached to Z lines), and (3) play a role in a transmission of nervous impulses from the sarcolemma to the myofibrils
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I bands
light areas near the Z lines consisting of thin, actin myofilaments
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A bands
dark areas consisting of both the thin myofilaments and the thick, myosin myofilaments
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H zone
slight variation in the shading of the A band due to absence of the actin myofilaments
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sarcoplasm reticulum
network of tubules and vesicles surrounding myofibrils within a muscle cell; consists of T tubes, which are parallel to Z lines, longitudinal tubules which run parallel to myofibrils, and cisternae (stores Ca++).
59
Triad
2 cisternae and T tubule
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H zone and I band during muscle contraction
they shorten, causing z lines to get closer
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basic functional unit of a muscle cell
sarcomere
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2 roles of calcium during muscle contraction
1) influx of Ca++ into the axon terminal stimulates the release of AcH (Contraction- step 1) 2) binding of calcium to regulatory sites on troponin remove the inhibition between actin and myosin (contraction- step 4)
63
3 roles of ATP in muscle contraction
1) release of previously stored energy drives the power stroke of the myosin S-1 head resulting in the pulling (sliding) of actin over myosin (Contraction- step 5) 2) new molecule of ATP binds to myosin S-1 head causing the dissociation of actin and myosin; myosin ATPase breaks ATP down into ADP, Pi, heat, and energy which is used to tilt the myosin S-1 head back down and away from actin to the resting, relaxed position (contraction- step 6) 3) ATP is used to actively pump Ca++ back into the sarcoplasmic reticulum cistern when the nerve impulse stops (relaxation- step 1).
64
3 fundamental principles of exercise phys
1) peak rate of muscle contraction (peak twitch rate) is dependent on myosin ATPase activity and the size (thickness) of the motor axon 2) maximal force (tension) that a muscle can generate is dependent on the amount of actin-myosin binding that is taking place 3) continuation of muscle contraction is dependent on the ability to recycle ATP
65
How fast do twitches occur during sustained muscular contraction
100-200 per second
66
3 basic types of muscle fibers
1) SO- slow twitch, type I, or red fibers 2) FOG- fast twitch oxidative glycolytic, type IIa, or intermediate 3) FG- fast twitch glycolytic, type IIb, or white
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3 basic types of muscle fibers
1) SO- slow twitch, type I, or red fibers 2) FOG- fast twitch oxidative glycolytic, type IIa, or intermediate 3) FG- fast twitch glycolytic, type IIb, or white
68
2 methods used to determine muscle fiber types
1) staining the tissue for the presence of various anaerobic and oxidative enzyme as well as enzymatic indicator of muscle fiber contraction speed - stains for TWITCH based on MYOSIN ATPase: dark= fast twitch, light = slow twitch - stains for ENDURANCE based on SDH (succininc dehydrogenase): dark= high oxidative, light= low oxidative (or glycolytic). 2) Assessment of myosin ATPase stability under various alkalinity (high pH or base) and acidity (low pH conditions) - ST= acid stable and basic labile - FOG= basic stable and acid labile - FG= basic stable and acid labile, also some stability after intermediate acid exposure - llc= exhibited some stability at all of the pH conditions; typically represent 0-2% of total fibers, probably at most 5% *dark indicated stable myosin ATPase and light indicates labile myosin ATPase
69
twitch and tension properties
FT motor units are much quicker to peak tension (30-40 msec) where ST motor units take longer (>100 msec) as FT motor units have greater concentrations of myosin ATPase and thicker axons; FT motor units also develop greater peak tension than ST motor units due to greater actin-myosin binding
70
endurance properties
FG motor units drop to 20% of maximal force production after about 2 minutes of contraction. FOG motor units maintain 90% of maximal force production after 2 minutes, but drop to 20-30% after 60 minutes. SO motor units still maintain about 90% of max force after 60 min. *SO and FOG motor units have greater endurance capabilities due to greater oxidative characteristics (greater mitochondrial density, concentration off oxidative enzymes, capillary density, and intramuscular fat stores)
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Fast twitch motor units
- neurons have larger cell bodies - neurons have thicker axons - require higher levels of neural; stimulation in order to depolarize and propagate neural impulses - propagate neural impulses faster than ST motor units - used less frequently, but twitch at faster rates; used during max effort (high intensity) slow speeds of movement, high intensity fast speeds of movement, during low intensity, long duration tasks when ST motor units become fatigued, and during the initiation of movement and maintenance of balance.
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slow twitch motor units
- neurons have small cell bodies - thinner axons - require lower levels of neural stimulation in order to depolarize and propagate neural impulses - propagate neural impulses more slowly than FT motor units - used more frequently, but have slower twitch capabilities; used during high intensity, slow movements and during low intensity, long duration tasks
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size principle
motor units whose neurons have a smaller cell body (ex: ST motor units) are generally recruited first followed by motor units whose neurons have a larger cell body (FT motor units)
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what came first, motor neuron or fiber type?
cross innervation studies indicate that "neurons dominate the response characteristics of the muscle tissue" due to either (theories) axoplasmic flow of a genetic substance theory or use-disuse theory
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variability in muscle fiber types
- basically normal distribution in both men and women - 50% FT and ST for most individuals - muscle type differentiation probably begins prior to birth during fetal life due to genetics - men slightly greater ST fibers than females on avg - training can modify fiber type distribution - success is probably a product of both nature and nurture (genetics and training)
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motor unit
collection of commonly innervated fibers
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general characteristics of a motor unit
- each is homogenous in fiber type composition (either all SO, FOG, FG) - each type of motor unit differs in sensitivity to stimulation (SO is easiest, FG is hardest) - each operates on "all or none" principle: all fibers in unit are equally sensitive to neural stimuli
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Force production determinants
- # of fibers within active motor units - # of motor units activated - size of fibers within active motor units (Hypertrophy (size)) - balance between stimulation and inhibition neurotransmitters (ACh) vs Gamma amino butyric acid (GABA) - frequency of impulses - initial length of muscle fibers: max tension is generated in a muscle when the length of the muscle is about 120% of resting length. **stretching increases actin and myosin binding - angle of pull: mechanical arrangement - architecture (configuration) of tendon and muscle fibers
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Fusiform
parallel fibers running the length of the muscle. longer muscle fibers have greater range of mvmt but greater injury risk
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penniform
fibers arranged diagonal to the direction of pull. short muscle fibers have short range of mvmt but great power and resistance to injury
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fatigue on force production
- metabolic by-products (lactic acid from anaerobic glycolysis, and ketone bodies from beta (fat) oxidation)= decrease pH which interferes w the Ca++ release, actin-myosin binding, and ATP breakdown, and myosin ATPase activity - depletion of neurotransmitter: neural fatigue - depletion of phosphagens
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factors influencing speed of mvmt
- thickness/ size of axon (ex: myelination) -myosin ATPase -muscle fiber type composition - Increase force vs decrease resistance increase acceleration= increase force/decrease mass -increase coordination
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hyperplasia
increase in muscle cells from training
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effects of training on muscle fiber type
* type 1= ST, type 2= FT - 18 weeks of aerobic and 11 weeks of anaerobic training resulted in significant increases in type 1 fibers and decreases in type 2c fibers in aerobically trained and opposite in anaerobic trained - sprint training increases the % of type 2 fibers by 23% and decrease in % of type 1 fibers after 6 weeks of training - THEREFORE, transformation in muscle fiber type w chronic activity is possible
85
Does strength training compliment endurance training and does endurance training compliment sprint training?
- -addition of strength training to an endurance training program (low volume and low intensity; 1-3 sets of 8-10 exercises), will increase time to exhaustion while performing a submit workload (70-80% of LRM, 2-3 days/week) - addition of endurance training to a strength program may reduce or compromise the potential strength gains from strength training if frequency of strength training is more than 3 days per week and/or some muscle groups are used in training programs
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3 primary sources of fatigue
1) metabolic by-products- lactic acid accumulation 2) depletion of neurotransmitter (ACh in motor neuron axon terminal) 3) depletion of the intramuscular phosphagen stores (adenosine triphosphate (ATP) and creatine phosphate (CP))
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is rate of muscle fatigue related to muscle fiber type?
yes. greater distribution of fast twitch muscle fibers in the working muscles will result in an earlier onset of fatigue; fast twitch muscle fibers (particularly FT glycolytic FG) have much lower oxidative capabilities and endurance capabilities compared to ST oxidative muscle and to a certain extent, the FOG)
88
primary factors influencing speed of mvmt
-dependent on thickness or myelination of the motor neuron axon and concentration of myosin ATPase in the muscle tissue. 1, about 25% of the difference in speed of mvmt capabilities can be attributed to amount of FT 2. greater force production, greater speed AND greater acceleration, greater speed. THEREFORE, increase in force production capabilities or a decrease in excess fat weight will increase potential speed 3. greater coordination via synchronous recruitment of agonist and antagonist muscle groups
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Anaerobic metabolic pathways (phosphagen (ATP-CP))
1) occurs in the sarcoplasm of the muscle cell 2) substrates: ATP and CP 2) primary energy system during high intensity exercise beginning at the onset of exercise lasting for up to 20-30 sec of continuous activity 3) the power (kcal/min) is limited by enzymes involved in breakdown (myosin ATPase) and replenishment (creatine phosphokinase and adenylate kinase) of ATP 4) capacity is limited by the phosphagen stores in muscle tissue, which is greater in a trained individual as well as an individual w more muscle mass
90
Anerobic metabolic pathways (Lactic acid)
1) occurs in sarcoplasm 2) substrates: glucose and glycogen 3) primary energy system during moderately high intensity for 30 sec- 2/3 min 4) power limited by enzymes involved in breakdown of glucose and glycogen (hexokinase, phosphorylase, phosphofructokinase, pyruvate kinase) 5) capacity limited by body's tolerance to lactic acid. training increases individual's tolerance to lactic acid by reducing lactic acid production and or increasing lactic acid clearance during exercise
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Aerobic metabolic pathways (AEROBIC GLYCOLYTIC (CARBOHYDRATE OXIDATION))
1) occurs in mitochondria 2) substrates: glycogen and glucose 3) primary energy system during moderate intensity exercise lasting 4-5 min, up t0 2-3 hours of continuous activity 4) power limited by enzymes involved in breakdown of glucose and glycogen, enzymes involved oxidative process in mitochondria, and oxygen availability provided by cardiorespiratory and circulatory systems 5) capacity limited by muscle and liver glycogen stores in the body. Training and carb loading increases glycogen stores in the body; further, the ingestion of carb replacement fluids during exercise increases carb availability for aerobic glycolysis
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Aerobic metabolic pathways (BETA (FAT) OXIDATIVE METABOLISM)
1) occurs in mitochondria 2) substrates: free fatty acids from intramuscular triglyceride stores, and adipose tissue triglyceride 3) primary energy system, during low intensity exercise 4) power limited by enzymes involved in mobilization of fat, breakdown of fat, enzymes involved in oxidative process in mitochondria, and O2 availability provided by cardiorespiratory and circulatory systems 5) capacity limited by intramuscular and adipose fat stores in the body which is unlimited. BUT carbs are needed to "primp the pump" for fat utilization as an energy source. - training increases intramuscular fat stores
93
glycogen sparing
during low to moderate intensity exercise, fat is primary energy source. however, some carbs are needed to prime the pump for fat usage. when citrate levels in krebs cycle are high, they will negatively feedback and inhibit PFK activity (rate limiting enzyme of glycolysis), which slows down rate of glycolysis. This is glycogen sparing ** when citrate inhibits PFK to spare glycogen to form oxaloacetate to prime the pump for fat usage
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Priming the pump
glycogen is spared (from glycogen sparing) to prime the pump for fat usage during low to moderate intensity exercise for long durations ** CHO-> pyruvate -> oxaloacetate which combines w acetyl CoA from fat to form citrate
95
if carbs are not available to prime the pump for fat usage, the excess breakdown of fatty acids may result in the formation of what negative by-product?
ketone bodies- which will decrease pH and affect muscle contraction
96
4 ways ATP is synthesized
1) oxidative metabolism's ability to accept pyruvate into Krebs cycle via formation of acetyl CoA or oxaloacetate, which is dependent on oxygen availability in ETS and enzymatic activity of the cytochromes in ETS, located in mitochondria 2) ability of electron transport system to accept NADH+H+ and FADH+H+, which is dependent on O2 availability in the ETS and enzymatic activity of cytochromes in ETS 3) ability to form alanine from the excessive breakdown of carbs, which is dependent on enzymatic activity of alanine transaminase (converts pyruvate into alanine) 4) ratio of M-LDH (forms lactate) to H-LDH (clears lactate); ratio tends to be higher in the fast twitch glycolytic fibers than Slow twitch oxidative fibers
97
net ATP from anaerobic glycolysis (lactic acid)
2 ATP
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net ATP from aerobic glycolysis (carbohydrate oxidation)
SKELETAL: 36 ATP CARDIAC: 38 ATP
99
for every molecule of acetyl CoA that enters Krebs cycle, how many ATP can be synthesized?
12 ATP
100
hoe many ATP can be synthesized in the electron transport system if NAD and FAD carry the pairs of H+ and their associated electrons from glycolysis, krebs cycle, or beta oxidation to the electron transport system
NADH+H (3 ATP) | FADH+H (2 ATP)
101
how many acetyl CoA molecules can be formed from a triglyceride molecule
3?
102
2 sources of fuel substrate and/or ATP from fat metabolism
- muscle lactate dehydrogenase (M-LDH): converts pyruvate in lactate - heart lactate dehydrogenase (H-LDH): converts lactate into pyruvate
103
for each gram of fat and carb, about how many kcal may be yielded?
9kcal/gram
104
4 fates of pyruvate
1) lactate (ANAEROBIC): decreases the pH of the muscle tissue thereby interfering w muscle contraction. Lactate is converted back into pyruvate for entrance into the Krebs cycle in the heart, liver, kidneys, and high oxidative slow twitch skeletal muscles 2) Alanine (ANAEROBIC): acts as reservoir for the excessive breakdown of carbohydrates under anaerobic conditions, there minimizing the formation of lactate; alanine is converted back into glucose in the liver 3) Acetyl CoA (AEROBIC): acetyl CoA is the common entry molecule for both fats and carbs into Krebs cycle 4. Oxaloacetate (AEROBIC): the conversion of pyruvate to oxaloacetate in order to combine w acetyl CoA from fat breakdown is known as priming the pump for fat usage
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ANAEROBIC phosphogen ATP-CP used during:
0-30 sec high intensity
106
ANAEROBIC GLYCOLYSIS or LACTIC ACID used during:
30 sec- 3/4 min high intensity
107
AEROBIC GLYCOLYSIS or CARB OXIDATION used during
3/4 min- 2/3 hours moderate intensity
108
AEROBIC BETA (FAT) OXIDATION used during
continuous low intensity
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hormones influencing mobilization of fat from adipose tissue
Hormones sensitive lipase (HSL)
110
glylcogenolysis
FG fibers
111
lipolysis
intramuscular (SO fibers-NEp) and adipose tissue (Ep and NEp)
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basic principles of carb loading
- effective and safe way of improving endurance performance in sporting events lasting longer than 60-80 min that are performed at an exercise intensity of 65-85% of max oxygen uptake or 75-85% of max heart rate. - appropriate for events such as distance cycling, running, swimming, and cross country skiing where muscle glycogen depletion is a factor limiting performance. - high carb diet will result in muscle glycogen super compensation thereby enhancing performance during moderate intensity, long duration exercise