Lecture 1 - Intro Flashcards Preview

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Flashcards in Lecture 1 - Intro Deck (52)
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1

Potential for drug-receptor binding.

Affinity

2

Binding site w/ biological effect.

Receptor

3

Capacity to produce a biological effect.

Intrinsic activity

4

Having intrinsic activity and affinity.

Agonist

5

Affinity without intrinsic activity.

Antagonist

6

A stereospecific phenomenon whereby a bound ligand influences specificity of a second site

Allostery

7

Efficacy

[affinity] x [intrinsic activity]

8

'effective' concentration in 50% of subjects

EC50

9

'effective' dose in 50% of subjects

ED50

10

'inhibitory' concentration in 50% of subjects

IC50

11

Result in chronic antagonism.

hypersensitivity

12

minimum amount of drug producing maximum therapeutic effect

maximum dose

13

Low intrinsic activity with potency and affinity within therapeutic range.

partial agonist

14

Drug --> Body

Pharmacodynamics

15

Body --> Drug (ADME)

Pharmacokinetics

16

Drug --> Disease

Pharmacotherapeutics

17

Science of drug dosing

Posology

18

response to a give dose

Potency

19

Loss of pharmacological effect.

Resistance

20

Ability to produce a desired effect versus adverse effect.

Selectivity

21

Ability to act at a specific receptor.

Specificity

22

Rapidly decreasing therapeutic response.

Tachyphylaxis

23

congenital malformation

Teratogenesis

24

Amount of active drug reaching target tissue.

Bioavailability

25

LD50:ED50 or TD50:ED50

therapeutic index

26

Diagnostic pharmaceutical agent

DPA

27

Therapeutic pharmaceutical agent

TPA

28

insulin

Supplemental drug type

29

glucose

Supportive drug type

30

low dose aspirin

Prophylactic drug type