Lecture 1 - Intro Flashcards
(21 cards)
Immune System
Cellular & molecular components responsible for immunity
Aberrant Cells
Cells that lost expression of self (cancer)
HIV targets which cells?
Helper T cells
Cells & Molecules of Innate Immunity
Barriers NK Granulocytes Dendritic Cells Complement Defensins Cytokines
Cells & Molecules of Adaptive Immunity
T cells
B cells
Antibodies
Defensins
Antimicrobial Peptides
-amphipathic molecule inserts into microbial membranes to make pores
Organelle in sweat, tears, saliva? FXN?
Lysozyme
-breaks down peptidoglycan of bacterial cell walls
PRR?
Pattern Recognition Receptors
- receptors on innate immune cells
- recognize PAMPS
Two types of adaptive immunity
Humeral - b cell/antibody
Cell Mediated - T cell
Antibodies are present in…. & defend against?
blood, lymph, bodily fluids, tissues
Extracellular Pathogens
T cells defend against?
Intracellular pathogens & tumor cells (induce apoptosis)
B & T cell receptors?
BCR - b cell
TCR - t cell
Created by somatice recomb. of gene segments
Each receptor is unique on each cell
When B & T cells activated they…?
Clonal proliferation & differentiation into effector and memory cells
Cytokines secreted by T cells can….?
enhance macrophage function
Cytokines secreted by macrophages can…?
direct T cell differentation
Cytokines Gen. FXN
Regulate immune response in active and innate immunity
Cytokines are
intracellular regulatory proteins
Cytokine Pleiotropy
One Cytokine w/ different effects
Cytokine Redundancy
Two or more cytokines w/ similar fxn
Cytokine Synergy
Combined effect of 2 cytokines greater than summation of 1 type
Cytokine Anatagonsim
Cytokines have opposite effects
