Lecture 3 - Lymph Tissue

Question 1

Primary Lymph Tissue FXN & Organs

Answer 1

-Maturation of WBCs
Bone Marrow
Thymus

Question 2

Secondary Lymph Tissue FXN & Organs

Answer 2

-Activation of Lymphocytes
Lymph Nodes
Spleen
MALT
Tonsils

Question 3

Location of hematopoesis fetal to adult

Answer 3

Yolk sac
Liver/Spleen
Bone Marrow

Question 4

Red Marrow

Answer 4

• location of hematopoiesis
• filled w/ stromal cells, HSC, fibroblasts
• Site of B, NK maturation
• Site of T cell formation

Question 5

Thymus Stromal Cells

Answer 5

Macrophages
Dendritic Cells (Conventional)
Thymic Epi Cells

Question 6

Thymus is site of?

Answer 6

T cell maturation/differentiation

Question 7

B Cell Location in Lymph Node

T Cell Location in Lymph Node

Answer 7

Follicle (b cell)

Paracortex (t cell)

Question 8

Thymus gross structure?

Answer 8

Cortex & Medulla

Question 9

Lymphocyte entrance into lymph node?

Answer 9

• Via HEV (if from blood)

- Afferent vessel (if bound antigen in tissue)

Question 10

Lymphocyte exit from lymph node?

Answer 10

Efferent vessel

Question 11

Swollen lymph nodes due to?

Answer 11

Bacterial or viral infection (normally)

Allergic reaction, arthritis, cancer (possible causes)

Question 12

Lymph flows from thoracic duct into?

Answer 12

Subclavian V.

Question 13

Spleen (red vs. white pulp)

Answer 13

Red - phagocytosis RBC, antigens, microbes

White - lymph tissue

Question 14

B Cell Location in Spleen

T Cell Location in Spleen

Answer 14

Follicle (b cell)

Periarteriolar lymphoid sheath (PALS) (t cell)

Question 15

Spleen Gross Structure

Answer 15

Encapsulated organ w/ white and red pulp zones

Question 16

Spleen Gross Function

Answer 16

Filter blood and remove antigen, microbes, old RBC

Question 17

Asplenia at risk for?

Answer 17

Infection, normally via ENCAPSULATED bacteria

Question 18

MALT & Tonsil FXN & Structure

Answer 18

• Defend Mucosal Surfaces
• collections of fibroblasts & WBCs
• MALT (loose) uncapsulated
• Tonsils - partially capsulated

Question 19

Steps of Cell Migration

Answer 19

Extravastation
-movement of WBC thru vessel wall into tissue (uses integrins & selectins)
Chemotaxis
-Directed movement via chemokines

Question 20

B Cell Migration to 2 Lymph Organ

Answer 20

• CXCL13 secreted from follicular dendritic cells (FDCs)

- CXCR5 binds CXCL13 & guides via chemotaxis

Question 21

T Cell Migration to 2 Lymph Organ

Answer 21

• CCL19 & CCL21 secreted from stromal cells of T zone

- CCR7 binds CCL19 & CCL21 & guides via chemotaxis

Question 22

Lymphocytes are constantly circ. btw blood & 2 lymph structures. How?

Answer 22

• spleen via blood vessels

- Lymph node, HEV in and lymph system to subclavian v. out