Lecture 10: Differentiation and Functions of CD4+ T cells Flashcards Preview

Immunology 2.0 > Lecture 10: Differentiation and Functions of CD4+ T cells > Flashcards

Flashcards in Lecture 10: Differentiation and Functions of CD4+ T cells Deck (20):
1

Langerhan's cells are immature DCs which do not express high levels of 

B7

2

Alpha/Beta chains of TCR have ____ intracellular domains

very short intracellular domains 

3

CD3 proteins (gamma, delta, epsilon, and zeta) have ____ cytoplasmic tail

long 

4

B7(CD80/CD86) are co-simulatory molecules expressed on 

professional APCs

5

B7 moleces plug into CD___ on T cells

  • CD28
    • Co-simtulation can be consider as "an amplifier" that improve the signal
    • with co-stimulation, about 100 fold fewer of clustered TCRs are needed for activation 

6

Subsets of CD4+ cells

  • Th1 cells
    • activate a cell-mediated immune response
  • Th2
    • activate an Ab-mediated immune response
  • Th17 cells 
    • involved in inflammation and anti-bacterial response 
  • Treg

7

8

9

cytokines derived from T cells 

  • IL-2
    • T cell proliferation
    • Treg survival
  • IFN-gamma
    • activation of marophages
  • IL-4
    • B cell isotype switching to IgE
  • IL-5
    • Activation of Eosinophils
  • IL-17
    • Stimulation of acute inflammation
  • IL-22
    • Maintenance of epithelial barrier function
  • TGF-beta
    • Inhibition of T cell activation
    • differentiation of Treg cells 

10

cytokines and transcription factors responsible for Th1 development

  • Cytokines
    • IL-12
    • IFN-gamma
  • Transcription factors 
    • T-bet
    • STAT4
    • STAT1

11

Cytokines and Transcription factors responsible for Th2 development

  • Cytokine
    • IL-4
  • Transcription factor 
    • GATA-3
    • STAT6

12

Cytokines and Transcription factors responsible for Th17 development

  • Cytokines
    • IL-1
    • IL-6
    • IL-23
    • TGF-beta
  • Transcription factors
    • RORgammat (orphan nuclear receptor)
    • STAT3

13

IFN-gamma produced by the Th1 cells amplifies Th1 development and inhibits the development of 

Th2 and Th17

14

CD40L gene is located 

on the X-chromosome

15

Nontraditional gamma/delta T cells do not express

They have TCRs and CD3 but do not express CD4 or CD8 coreceptors 

16

Functions of gamma/delta T cells

  • First line of defense
  • regulatory cell
  • bridging between innate and adaptive responses
  • (note these cells are abundant in the intestine, the uterus, and the tongue)
  • (are considered component of both innate and adaptive immunity)
    • much less diverse than Alpha/beta TCRs

17

18

Lipids and glycolipids should be presented within non-polymorphic ____ molecule in order for NKT cells to identify them

CD1d

19

Activated NKT cells produce large quantities of 

  • IFN-gamma
  • IL-4
  • GM-CSF

20

Dysfunction or deficiency of NKT lead to

  • Autoimmunity
  • Cancers 
  • Progression of asthma