Lecture 16: Immunity to Microbes Flashcards Preview

Immunology 2.0 > Lecture 16: Immunity to Microbes > Flashcards

Flashcards in Lecture 16: Immunity to Microbes Deck (11):
1

surface lipopolysaccharides may activate the _____ complement pathway or _______ pathway

alternative or mannan-binding lectin complement pathway

2

C3a and C5a are chemoattracts but also function in activation of 

mast cells 

3

in latent viral infections, the viral DNA may be integrated into the DNA of infected cells, but ______ is produced

no infectious virus (ex. herpesvirus and poxvirus families)

4

C-reactive protein (CRP) and serum amyloid (SAP) are prominent members of pentraxin family, which are able to bind to _____ and _____ to  activate classical pathway

  • bacterial surfaces (ligand for CRP is typically phosphorylcholine and ligand for SAP is typically phosphatidylethanolamine)  and the globular heads of C1q

5

What is the strongest attractant of neutrophils 

IL-8 

6

Local inflammation in lymph node leads to upregulation of 

adhesion molcules (HEVs) on lymph nodes

7

relatively low affinity interaction is enhanced by the five adhesion sites on IgM, leading to higher _____ of the binding 

avidity 

8

Infections caused by pathogenic extracellular bacteria have two principal mechanisms:

  1. Tissue damage is caused by inflammation at the site of infeciton 
  2. bacteria produce toxins which have diverse pathologic effects 
    • Endotoxins: which are components of bacterial cell walls 
    • Exotoxins: which are secreted by the bacteria 

9

What are the principal mechanisms of innate immunity to extracellular bacteria

  • complement activation 
  • phagocytosis 
  • inflammation 

10

  • Bacterial ______ and ____ activate the alternative pathway

  • peptidoglycan (gram-positive)
  • LPS (Gram negative)

11

Anaphylatoxins

  • C4a
  • C3a
  • C5a