Lecture 11 - Cerebellum Flashcards Preview

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Flashcards in Lecture 11 - Cerebellum Deck (11):
1

Cerebellum

-coordinates volitional movement by comparing the motor plan with movements as they occur --> feedback to cerebrum and brainstem for correction
-tightly connected to vestibular nuclei
-also does other things

2

Lesions of cerebellum or connections

-lateral: IPSI limb ataxia
-medial: gait ataxia
-lesion more medial than lateral:
vertigo (feeling/hallucination of movement)
Nystagmus (involuntary movement pattern of eye)
Dysarthria (abnormal speech, slurred)

3

Structures

Vertical
-Vermis
>Anterior lobe of cerebellum
>midline
Medial hemisphere (paravermis)
lateral hemisphere

Horizontal
-Primary fissure separates Ant and Post lobes
-Horizontal fissure separates (bisect)
-flocculonodular lobe (superior surface)

Cerebellar peduncles (inf, mid, sup)

Deep nuclei
-Dentate
-interposed (emboliform, globose)
-fastigial

medial = trunk/axial
lateral = limbs

4

Blood supply

PICA (posterior lobe)
AICA (middle
SCA (anterior)

5

Wiring in general

1. input to purkinje cells in cortex
-climbing fibers from CONTRA inf. olive
-mossy fibers from several sources to interneurons
2. integration in deep nucleus
3. output from deep nuclei through peduncles to various locations

6

Inputs

corticopontine and pontocerebellar tracts
-motor plan from motor cortex (comes down corticopontine)
-at pons, synapse on 2nd neuron --> CONTRA
-other info from other cortical areas

spinocerebellar tracts and brainstem nuclei
-unconscious position sense
-vestibular sense
-IPSI

7

Outputs

superior cerebellar peduncles
-ventral anterior and ventral lateral nuclei of thalamus
-red nucleus

multiple brainstem nuclei
-direct to vestibular nuclei

Cortex --> deep --> superior cerebellar peduncle --> thalamus/red nuclei

8

Cerebellar symptoms/signs

Ataxia: incoordination
-limb: finger-to-nose and heel-to-shin testing
dysmetria: missing target
intention tremor: kinetic, on approaching a target
dysdiadochokinesia: abnormal rapid alternating move
-gait: wide-based, unsteady
-trunk: unable to sit unassisted

Dysarthria: abnormal enunciation
Vertigo, nystagmus, nausea

9

Lateral cerebellar syndrome

dysfunction of lateral cerebellum or connections cause:
-ataxia of IPSI limbs (double cross)
-dysarthria
-vertigo, nystagmus, nausea

10

Medial cerebellar syndrome

-ataxia of gait and trunk
-dysarthria
-vertigo, nystagmus, nausea

11

Cerebellar role in other stuff

-role in motor planning (lateral hemisphere
-correction (medial hemisphere)
-motor learning (connection to inf. olive)
-aspects of cognition