Lecture 12 - Heamopoeisis

Question 1

how do circulating cells in the body break down ?

think differentation

Answer 1

a heamtopoeitc stem cell (heamocytoblast)

divides into two KEY branches a lymphoid progenior and a myeloid progenior

Question 2

what is the use of recombinant growth factors (hormones) in heamopoiesis

Answer 2

stimulate a pathway of differentiation to make the body produce a specic cell

interleukin for Natural killers and T,B lymphocytes

G-CSF for Neutrophils

Erythropoietin for RBC’s

Thrombopoietin for Megakaryocte/thromboctyes/platlets

Question 3

where is the myleoblast on the tree

what cells does it go on to make
what are their roles

Answer 3

Myeloblast - branch again to become the neucleocytes:

Basophil - trigger immune response

Neutrophil - production regulated by G-CSF - kill organisms with enzymes

Eosinophil -inflammation

monocyte - will become a Macrophage when in tissue - identify bugs and trigger an immune response - antigen presenting

Question 4

what are the cells in the myleoid progenior end of tree

what are their functions

Answer 4

the myleoid progenior will go on to make :

a megakaryocyte - produces Thrombocytes - the platlets in the clotting process - srface for clotting factors to form clot - forms fibrin clot to repair breaks

thrombopoeitin is a hormone that will produce these cells

ertyhrocytes (RBC) will be triggered by Erythropoietin (hormone)

Mast cells

Myeloblast - branch again to become the neucleocytes:

Question 5

what are the cells in the lymphoid end of the tree

what are their functions

Answer 5

lympoid progenior - stimulated by interlukins

Natural killer cell - stimulates infected cells to undergo apoptosis

T lympocyte - reconginse foreng proteins and activate other cells - neutrophils, monocytes, B cells
directly kill

B lymphoycte - produce antiboides once faced with foreign antigen

palsma cell