Lecture 12- Skin diseases

Question 1

a … is a flat circumscribed area less than 5 mm

Answer 1

macule

Question 2

a … is a flat circumscribed area greater than 5 mm

Answer 2

patch

Question 3

a … is an elevated lesion that is less than 5 mm

Answer 3

papule

Question 4

a … is an elevated lesion that is greater than 5 mm

Answer 4

plaque

Question 5

a … is a discrete pus-filled lesion

Answer 5

pustule

Question 6

a … is a fluid filled lesion less than 5 mm

Answer 6

vesicle

Question 7

a … is a fluid filled lesion greater than 5 mm

Answer 7

bulla

Question 8

3 acute inflammatory dermatoses

Answer 8

urticaria
acute eczema
erythema multiforme

Question 9

clinical features of …. are erythematous, edematous, and pruritic papules and plaques (wheals)

Answer 9

urticaria

Question 10

individual hive last …. but episodes can continue for …

Answer 10

less than 24 hrs

weeks

Question 11

pathogenesis of acute urticaria

Answer 11

mast cell degranulation–> increased dermal vascular permeability–> dermal edema

Question 12

urticaria is which type of hypersensitivity?

Answer 12

immediate type 1 (IgE)

Question 13

inciting factor of urticaria

Answer 13

medications (opiates, abx)

Question 14

tx of urticaria

Answer 14

antihistamines

Question 15

clinical features of … are pruritic inflammatory erythematous papules and scaly plaques that can become vesicular and crusted

Answer 15

acute eczema

Question 16

with acute eczema, skin thickens over time due to…

Answer 16

acanthosis

Question 17

in acute eczema you see …. on histo: epidermal edema, perivascular lymphocytic infiltrate and mast cell degranulation

Answer 17

spongiotic dermatitis

Question 18

types of eczema

Answer 18

atopic
allergic contact
photoezematous
irritant dermatitis

Question 19

…. eczema usually has a genetic predisposition and has a triad with allergies and asthma and is is more common in childhood, outgrow as adult

Answer 19

atopic

Question 20

allergic contact dermatitis is a type … hypersensitivity rxn and is … mediated ( poison ivy)

Answer 20

IV

CD4+T

Question 21

… is a hypersensitivity rxn due to medications such as sulfonamides, PCN, NSAIDS, hydroxyquinone and infections such as HSV and mycoplasma

Answer 21

erythema multiforme

Question 22

erythema multiforme is on the spectrum of

Answer 22

stevens johnson (mucosal involvement) and toxic epidermal necrolysis (TEN- full thickness epidermal necrosis)

Question 23

classic feature of erythema multiforme

Answer 23

targetoid lesion

Question 24

… is a chronic inflammatory dermatosis that affects 1-2% of the US population and is associated with heart disease and 10% can develop arthritis

Answer 24

psoriasis

Question 25

psoriasis is .... mediated

Answer 25

T cell (autoimmune)

Question 26

clinical features of .... are erythematous salmon-pink colored plaques with silvery scale. affected areas are usually the extensor elbows, knees, scalp, gluteal cleft. you will also see nail thickening and dystrophy

Answer 26

psoriasis

Question 27

... is when you can induce a lesion by local trauma in psoriasis

Answer 27

koebner or koebnerization

Question 28

a ... is when you get punctate bleeding when overlying scale is removed

Answer 28

auspitz sign

Question 29

... is caused by staph or strep pyogenes and is very contagious, more common in kids spreads by direct contact. starts as small macule often perioral/perinasal and enlarges with honey-colored crust (dried serum)

Answer 29

impetigo

Question 30

tx for impetigo

Answer 30

antibiotics

Question 31

3 blistering dermatoses

Answer 31

pemphigus vulgaris pemphigus foliaceus bullous pemphigoid

Question 32

... is lysis of intercellular jxns between squamous cells

Answer 32

acantholysis

Question 33

pemphigus... shows suprabasal acantholysis which means above basal cell

Answer 33

vulgaris

Question 34

pemphigus ... shows acantholysis subcorneal which means superficial epidermis at stratum granulosum

Answer 34

foliaceus

Question 35

pemphigus is a type ... hypersensitivity rxn and involves ... autoantibodies that bind to .... intercellular desmosomal proteins

Answer 35

2 IgG desmoglein type 1 and 3

Question 36

most common type of skin cancer

Answer 36

basal cell carcinoma

Question 37

Pruritic, purple, polygonal, and planar papules and plaques describes what?

Answer 37

lichen planus