Lecture 2- Gastrointestinal Pathology 2

Question 1

most common polyposis syndrome of the GI tract?

2nd most common?

Answer 1

Familial Adenomatous Polyposis

Peutz Jegher syndrome

Question 2

risk of affect patients of FAP developing colon cancer approaches…

Answer 2

100%

Question 3

…. requires more than or equal to 100 polyps to diagnose

Answer 3

FAP

Question 4

gardner’s syndrome is …. + …

Answer 4

FAP

extraintestinal lesions

Question 5

oral manifestations of Gardners syndrome

Answer 5

unerupted teeth
supernumerary teeth
mandib. cysts
inc. risk for odontomas
delayed tooth eruption
skin lesions
CHRPE

Question 6

… is the 2nd most common polyposis syndrome

Answer 6

Peutz Jegher syndrome

Question 7

… syndrome presents with melanin deposits around nose, lips, buccal mucosa, hands and feet, genitalia and perianal region. develop early in childhood

Answer 7

Peutz Jegher

Question 8

in idiopathic inflammatory bowel disease, … can occur in any portion of the GI tract starting with the mouth and …. is localized to the colon and rectum only

Answer 8

crohns disease

ulcerative colitis

Question 9

… are extensions into the colonic lumen that are hyperplastic, inflammatory, hamartomatous and adenomatous

Answer 9

colon polyps

Question 10

what is the most important predictor of malignant change in adenomas in the colon?

Answer 10

size

Question 11

familail adenomatous polyposis entails mutations of the … gene

Answer 11

APC

Question 12

estimated penetrance for adenomas in FAP is greater than …%

Answer 12

90%

Question 13

untreated polyposis leads to …% risk of cancer

Answer 13

100%

Question 14

CHRPE is…

Answer 14

congenital hypertrophy of retinal pigment epithelium

Question 15

2 polyposis associated syndromes with oral manifestations

Answer 15

Gardeners (FAP + extraintestinal lesions)

Peutz Jegher syndrome

Question 16

a common feature of …. is non-sun dependent freckling of the skin around the lips and the vermillion zone of the lips

Answer 16

Peutz-Jeghers syndrome

Question 17

…. involves GI hamartomatous polyps (intussusception) and pigmented macules of mucous membranes and skin

Answer 17

Peutz-jeghers

Question 18

average age of dx for peutz-jeghers?

Answer 18

23-26

Question 19

name 2 idiopathic inflammatory diseases

Answer 19

crohns

ulcerative colitis

Question 20

… disease presents with chronic diarrhea +/- blood with colicky abdominal pain and presents in young adulthood

Answer 20

crohns

Question 21

crohns disease can affect any portion of the GI tract , most often is seen in … and …

Answer 21

distal small bowel (ileum)

colon

Question 22

T/F oral involvement is often seen in crohns

Answer 22

true

Question 23

… disease is a segmented transmural inflammation of the bowel

Answer 23

crohns

Question 24

ulcerative colitis only affects the … and …

Answer 24

colon

rectum

Question 25

T/F oral involvement is often seen in ulcerative colitis

Answer 25

false. its rare

Question 26

in crohns disease you will often see "..." lesions and the bowel wall be ...

Answer 26

skip thick, stenotic

Question 27

crohns or UC? mucosal ulcer "cobblestone" diseased tissue lower than normal tissue

Answer 27

crohns

Question 28

benign stomach tumors

Answer 28

inflammatory or reactive leiomyomas

Question 29

malignant stomach tumors

Answer 29

adenocarcinoma (90-95%) lymphoma (4%) carcinoid (3%) spindle cell tumors (2%)

Question 30

gastric carcinoma represents ...% of all cancer deaths

Answer 30

3%

Question 31

most important prognostic indicators in adenocarcinoma of the colon?

Answer 31

depth of invasion and lymph node metastases

Question 32

TMN classification

Answer 32

T: depth of tumor 1. submucosa 2. muscularis propia 3. subserosa/pericolic fat 4. contiguous structures N: lymph nodes M: metastasis

Question 33

which presents with noncaseating granulomas? crohns or ulcerative colitis?

Answer 33

crohns

Question 34

UC is related to crohns but UC is limited to the ... and always involves the ...

Answer 34

colon rectum

Question 35

what is the term for this oral manifestation that can be seen in either UC or crohns: scattered, arc-shaped pustules on an erythematous mucosa at multiple oral sites with variable severity.

Answer 35

"snail track" or pyostomatitis vegetans

Question 36

in UC, 10% of patients develop IBD-associated arthritis of ....

Answer 36

temporomandibular joints

Question 37

2 benign small intestine tumors

Answer 37

adenoma | leiomyoma

Question 38

4 malignant small intestine tumors

Answer 38

adenocarcinoma carcinoid lymphoma sarcoma

Question 39

most common malignancy of the GI tract?

Answer 39

colon adenocarcinoma

Question 40

what kind of diet is a risk factor for colorectal cancer?

Answer 40

high fat, low fiber

Question 41

colorectal cancer is responsible for causing ...% of all cancer deaths in the US and is second only to lung cancer in cancer deaths

Answer 41

15

Question 42

there is an increased incidence of adenocarcinoma of the colon in ... patients

Answer 42

FAP