Lecture 13

Question 1

List some vaccination problems

Answer 1

Vaccination problems
inadequate response (vaccination failure)
adverse reactions
vaccinations are designed to cater for the mean of the population and so the vaccinations will not work for some individuals

Question 2

List the reasons for vaccine failure

Answer 2

reasons for vaccine failure 
incorrect administration 
inappropriate route of admin. 
death of live vaccine 
admin. to passively protected animal (young animal which is getting milk from mum with ab)
vaccine given too late 
wrong strain 
nonprotective ag used 
prior passive immunisation 
animal is immunosuppressed 
biological variation (individuality)
shit vaccine

Question 3

List the adverse vaccine reactions and what it leads to

Answer 3

Adverse vaccine reaction

• errors in manufacture or admin. which leads to immunosuppression, clinical disease, felt death
• toxicity which leads to fever, inflammation and pain
• inappropriate response leading to hypersensitivity, neurological and foreign body reactions

Question 4

Explain the relationship of ab present in mums milk and how this changes over time

Answer 4

maternally ab are transmitted via colostrum this is passive immunity
levels of protection
depends on the quality of mums colostrum and the amount consumed
at 4-6 weeks the ab levels decrease and by 16 weeks they are all gone during this time the babies own immune system starts works so as decrease the other increases