Flashcards in Lecture 14 - Asthma Deck (10):
Features of asthma?
episodic, chronic, life-threatening: swollen airways, excessive mucus
Diagnosis of asthma?
wheezing, airflow obstruction in lung fucntion test, history of: dyspnea, chest tightness, reversible ariflow limitation, family history of asthma or atopic disease
Lung function tests?
most common, usually early onset, environmental, positive family history,
Typical precedings of atopic asthma?
rhinitis, urticaria, eczema
Acute Phase Response?
inhalation of allergen causes immediate fall in lung function
to Th2 (cytokine releasing cells) rather than Th1 (IFN, IL, TNF) - cross inhibition
typically late-onset, respiratory tract infection relation, medication risk
synthesis of mast cells & eosinophils, causes prolonged bronchoconstriction, muxus secretions and vascular permeability -> edema (antagonists treat asthma)