Lecture 14 - Asthma Flashcards Preview

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Flashcards in Lecture 14 - Asthma Deck (10):
1

Features of asthma?

episodic, chronic, life-threatening: swollen airways, excessive mucus

2

Diagnosis of asthma?

wheezing, airflow obstruction in lung fucntion test, history of: dyspnea, chest tightness, reversible ariflow limitation, family history of asthma or atopic disease

3

Lung function tests?

PEF, spirometry

4

Atopic asthma?

most common, usually early onset, environmental, positive family history,

5

Typical precedings of atopic asthma?

rhinitis, urticaria, eczema

6

Acute Phase Response?

inhalation of allergen causes immediate fall in lung function

7

Genetic predisposition?

to Th2 (cytokine releasing cells) rather than Th1 (IFN, IL, TNF) - cross inhibition

8

Non-atopic asthma?

typically late-onset, respiratory tract infection relation, medication risk

9

Leukotriene role?

synthesis of mast cells & eosinophils, causes prolonged bronchoconstriction, muxus secretions and vascular permeability -> edema (antagonists treat asthma)

10

IgE role?

triggering mast cells causing inflammation