Lecture 15 - Asthma Treatment Flashcards Preview

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Flashcards in Lecture 15 - Asthma Treatment Deck (19):
1

Relievers?

provide relief from asthma symptoms, rapid onset short duration, smooth muscle relaxation, use as required e.g. asthma attack, exercise

2

Preventers?

long-term control, anti-inflammatory to prevent attacks, taken daily

3

three types of bronchodilators?

inhaled beta-adrenergic agonists, anticholinergic agents, xanthine drugs

4

Beta-adrenergic agonist asthma management?

relaxation of smooth muscle (bronchodilation), reduced vascular permeability & edema

5

Beat-adrenergic agonist mechanism?

beta receptor -> AC -> ATP into cAMP -> PKA -> Ca activated K+ channel -> smooth muscle relaxation and inhibition of mediator release

6

Alternate routes of administration?

oral, direct endotracheal instillation

7

Problems with toddler inhalation?

small tidal volume, small airways, rapid respiration, aversion to masks

8

Why use spacer?

More direct entry to the lung rather than stomach

9

Rapid action long duration b-adr asthma treatment?

Formoterol

10

Adverse effects of b-adr?

tremor, tolerance, hypokalemia, tachycardia

11

Prescription of LABA?

not as first base, only if all other therapies fail, does not relief

12

Anticholinergic effects?

reduce mucus secretion, bronchoconstriction and inflammatory response

13

Ach drug?

Ipratropium Bromide

14

Ipratropium Bromide characteristics?

slow onset, short duration, regular basis, low side effects (less tachyphylaxis)

15

Ipratropium Bromide problem?

reduced mucociliary clearance

16

Xanthine drug effects?

non-selective inhibition of phosphodiesterase (bronchodilation), activate HDAC (anti-inflammatory), adenosine antagonist

17

Effects of adenosine antagonism?

arrhythmia, CNS stimulation, gastric acid hypersecretion, diuresis

18

Theophylline positive effects?

bronchodilation, increased diaphragm strength, increase mucociliary clearance, decreased dyspnea, CV performance, dec. pulmonary artery pressure, diuresis

19

Theophylline side effects?

toxicity risk due to narrow therapeutic range - monitored by serum monitoring; nausea etc, seizure, hyperglycaemia