Lecture 15 Flashcards

(52 cards)

1
Q

hearing and balance depends on _____ of stereocilla?

A

mechanical bending

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2
Q

what are the properties of sound?

A
  1. sound and 2.pitch
  2. Sound
    - pressure disturbances produced by a vibrating object (altering areas of high and low pressure)
    - consists of many waves that pass a given point in a given time
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3
Q

What is the property of pitch?

A
  1. perception of different frequencies
    normal range 20 - 20,000 hertz (hz, cycles per second)
    - higher frequency = higher pitch
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4
Q

how does sound get to the inner ear?

A
  • sound enters external ear
  • sound transmission to middle ear
  • stapes transmits sound through the oval window
  • sound passes through cochlear duct (to move stereocilia)
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5
Q

where are sound waves transmitted?

A

into the cochlear duct causing the bending of Stereocilia

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6
Q

The stereocilia are protrude into _____ and the longest are connected to the gel like ______?

A

into the endolymph, into the tectorial membrane

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7
Q

how does the bending toward the tallest stereocila?

A
  • opens mechanically gated ion channels
  • activates K+ and Ca+ current causing depolarization
    (graded potential and release of glutamate)
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8
Q

How does bending away from the tallest stereocilia?

A
  • closes mechanically gated ion channels
  • hyperpolarization inhibits release of glutamate
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9
Q

cochlear nerve fibers transmit impulses where?

A

The brain

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10
Q

fibers near the oval window produce what sound?

A

(short and stiff)
- resonate with high frequency

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11
Q

fibers near apex (or away) from the oval window produce what sound?

A

(longer more floppy)
- resonate with lower frequency waves

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12
Q

The pitch of the sound is determined by where the stereocilia are on what?

A

based on the positions along the basilar membrane

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13
Q

How can loudness be detected?

A

by an increased number (frequency) of action potentials in the activated position
- (louder noise means greater amplitude and stereocilia remain in the activated position for a longer period of time)

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14
Q

What is sensorineural deafness?

A

damage to neural structures at any point from
- cochlear hair cells to auditory cortex
typically from gradual hair cell loss (loud noises, music)

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15
Q

what is tinnitus?

A

ringing in ears, in some cases damaged hair cells keep sending signals to the brain
- still hearing b/c of hair cells are still dropping neurotransmitters

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16
Q

what is conduction deafness?

A

blocked sound conduction to fluids of inner ear
causes:
- impacted ear wax
- perforated eardrum
- otosclerosis of the ossicles (hardening of the ossicles) elderly
- otitis media (middle ear infection)

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17
Q

What is otits media? causes and treatement?

A

middle ear infection
- cause of hearing loss in children
- shorter, more horizontal Eustachian tubes
Treatment?
- with antibiotics
- tubes are inserted through tympanic membrane

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18
Q

What does hearing aids do compared to cochlear implant?

A

hearing aids = amplifies sound
cochlear:
- bone conduction = passes through bone to tell inner ear
- cochlear implant = passes through all to tell cochlear with electrode on it to hear

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19
Q

What helps us with equilibrium and balance?

A

Saccule and utricle (macula)

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20
Q

Central cavity of the bony labyrinth contains what 2 membrane sacs?

A

Saccule - continuous with the cochlear duct
utricle - continuous with semicircular canals

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21
Q

Saccule and Utricle house what?

A

linear equilibrium receptor region (macula)
- respond to gravity and changes in position in head

22
Q

What do the Semicircular Canals do in response to movement?

A
  • rotational movement
  • lie in 3 planes of space
  • membranous semicircular ducts line each canal
23
Q

Ampulla of each canal houses rotational equilibrium receptor region called?

A

Crista ampullaris

24
Q

what is kinocilium and stereocilia?

A

Both are the longest stereocilium and are embedded in the otolith membrane
- studded with otoliths (tiny CaCO3 stones)

25
where do stereocilia point by the utricle and sacula?
Utricle = superiorly Saccule = laterally
26
Hair cells synapse with ___ nerve fibers?
Vestibular
27
what movements does the Utricle respond to?
horizontal movements - tinting head side to side - forward direction
28
What movements does the Saccule respond to?
responds to vertical movements - jumping up and down
29
At rest does the macula release neurotransmitter continuously?
yes, the movement motifies amount they release - therefore the brain is informed of changing position of head - (slow steady tonic release) tempo
30
What is the sensory receptor for rotational acceleration in semicircular canals?
The Crista Ampullaris (crista)
31
Where is the ampula?
at the bottom of the semicircular canal - ampulla is a swelling at the base of each canal
32
What is the major stimulus of the Crita? or the crista ampullaris?
rotational movements
33
the hair cells in the crista extend into where?
gel like mass called capula
34
what is the function of the crista at rest?
at rest - the capula sticks out straight into the endolymph
35
What is the function of the crista during rotational acceleration?
during rotational acceleration - the endolymph bends the capul in the opposite direction if rotation and depolarizes the cell
36
What is the function of the crista after gaining inertia?
after gaining inertia - rapid stop causes endolymph to keep moving in the direction of the rotation, and capula bends in the opposite direction
37
Describe the activation of the smell receptors?
1. odorant binds to its receptors 2. receptor activates g protein (golf) 3. g protein activates Adenylate Cyclase 4. Adenylate Cyclase converts ATP to cAMP 5. cAMP opens a channel causes Na and Ca influx - membrane depolarization and exocytosis of glutamate
38
What there is Ca influx what appends to smell?
olfactory adaptation - decreased response to sustained stimulus
39
What receptors are taste?
thermoreceptors, mechanoreceptors, and nociceptors - can influence taste
40
where is fungiform, foliate and vallate papillae found?
fungiform - top of tongue foliate vallate - on side wall of tongue
41
On the taste bud what are the 2 types of cells?
50 - 100 1. Gustatory 2. Basal - both epithelial cells
42
how is gustatory cells different then basal cells?
1. gustatory - taste cell - microvilli (gustatory hairs are receptors) - 5 different neurotransmitters 2. Basal - dynamic stem cells that replace gustatory epithelial cells every 7-10 days
43
What are the 5 taste sensations?
- salty - sour - sweet - bitter - unami (savory)
44
what does salty taste detect?
metal ions (inorganic salts)
45
what does sour taste detect?
H ions in solution (malic, ascorbic, and citric acid)
46
what does sweet taste detect?
sugars, saccharin, alcohol, and some amino acids
47
what does bitter taste detect?
alkaloids (plant based alkaline compounds) such as quinine and nicotine; also asprin
48
what does umami taste detect? (savory)
amino acids glutamate, and aspartate
49
how does binding of good chemical depolarize taste cell membrane? (tastant)
leading the neurotransmitter release eliciting action potentials on sensory neuron
50
When faced with salty taste the gustatory cell depolarizes and is caused by what?
tastes due to Na influx (directly causes depolarization - neurotransmitter = unknown
51
When faced with sour taste the gustatory cell depolarizes and is caused by what?
taste due to H+ (blocks K, or opens Na or Ca channels) - neurotransmitter: serotonin, GABA, norepinephrine
52
When faced with sweet, bitter , and umami taste the gustatory cell depolarizes and is caused by what?
are coupled to the G protein - gustducin ehich depolarizes the membrane through numerous pathways - neurotransmitters (ATP or acetylcholine)