Lecture 17 & 18 (Exam 2) Flashcards
Dual roles of a lipid bilayer –
1) A 2D liquid that allows lateral movement of proteins and lipids
2) A _________ barrier
Permeability
In _______ transport, no energy is needed and solutes travel down the concentration gradient.
Passive
In _______ transport, it is coupled to ATP hydrolysis and solutes travel against the concentration gradient.
Active
There are three general modes of transport, which are…
Antiporter
Symporter
Uniporter
There are three general categories of transporters –
1) _______ perform primary active transport.
2) _______ traverse the membrane without needing (extra) energy
3) _______ are used in passive transport
Pumps
Carriers
Channels
A P-type pump _________ itself.
Phosphorylates
This type of pump binds ATP.
ABC transporter (ATP Binding Cassette)
This type of pump uses ATP and was first found in yeast vacuoles.
V-type proton pump
This type of pump makes ATP (Phosphorylation factor).
F-type ATP synthase
In P-type ATPases which use primary active transport, one type is _____ potassium move into the cytosol and ______ sodium move to the outside. Their role is electrical excitation (neurons, muscles), gradient driving active transport.
2
3
Another type of P-type ATPase is when 2 ________ move out to the sarcoplasmic reticulum. This is at the muscle.
Calcium
Another type of P-type ATPase is when 1 _______ moves to the cytosol and 1 _______ moves to the stomach. The location is the stomach and its role is digestion/gastric pH.
K+
H+
In a P-type pump, there are 4 domains. This domain spans the lipid bilayer.
Transmembrane domain
In a P-type pump, there are 4 domains. This domain links the cytosolic domains to the transmembrane domain.
A/Actuator domain
In a P-type pump, there are 4 domains. This domain binds ATP.
N/Nucleotide binding domain