Lecture 18: Viscerosensory Afferents Flashcards

1
Q

What do visceral afferent neurons interface between?

A

visceral organs and the brain

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2
Q

What are the two visceral afferent pathways?

A

cranial visceral afferents and spinal visceral afferents

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3
Q

What is role of spinal visceral afferents?

A

send information to the brain about what is perceived in terms of the state of the internal organs

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4
Q

What is role of cranial visceral afferents?

A

send information to the brain about the function of the internal organs

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5
Q

Where are the cell bodies of spinal visceral afferents?

A

in the dorsal root ganglion

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6
Q

Approximately what percentage of inputs to the spinal cord are spinal viscerosensory afferents?

A

10%

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7
Q

Where do spinal visceral afferents terminate?

A

first terminate in the dorsal horn of the spinal cord

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8
Q

Where do spinal visceral ascending pathways lead to?

A

the thalamus, hypothalamus, pons/midbrain, rostral medulla and caudal medulla

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9
Q

What is the role of spinal visceral afferents?

A

visceral non-painful sensations, visceral discomfort and pain, referred pain, local organ feedback and shaping emotional state

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10
Q

What are all visceral organs innervated by?

A

either or both of the spinal and cranial visceral sensory neurons

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11
Q

What do spinal and visceral sensory neurons sense?

A

mechanical and chemical (and temperature) stimuli

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12
Q

Where do cranial visceral afferents first terminate?

A

in the solitary tract nucleus of the brainstem

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13
Q

What is the role of cranial visceral afferents?

A

visceral non-painful sensations, shaping emotional state relating to the body (interoception) and organ regulation, organ reflexes, neuroendocrine regulation

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14
Q

Where can the cell bodies for cranial visceral afferents be found?

A

nodose / inferior ganglion of the vagus
petrosal ganglion
jugular / superior ganglion of the vagus

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15
Q

What is the structure of a reflex?

A

sensor -> integration -> effector

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16
Q

What do cranial visceral afferents drive?

A

the autonomic nervous system

17
Q

Where do cranial visceral sensory neurons input?

A

to the brainstem

18
Q

What do cranial visceral sensory neurons sense?

A

mechanical and chemical stimuli

19
Q

What is a major physiological role of cranial visceral sensory neurons?

A

to initiate autonomic reflexes (to alter organ function)

20
Q

What initiates the baroreceptor reflex?

A

pumping of blood into the aortic arch activates aortic arch receptors which stimulate the vagus nerve
also blood entering the right and left interior carotid arteries activate carotid sinus receptors which stimulate the carotid sinus nerve which leads to nerve IX

21
Q

What is the baroreceptor reflex?

A

control of autonomic activity to the heart which provides a rapid means of adjusting cardiac output to match arterial blood pressure

22
Q

What is an important characteristic of baroreceptors?

A

always active (asleep or awake), phasic

23
Q

How many baroreceptors are unmyelinated?

A

90% of baroreceptors are unmyelinated “C-fiber”

24
Q

What are characteristics of myelinated baroreceptors?

A

high sensitivity and high fidelity

25
Q

What are characteristics of unmyelinated baroreceptors?

A

low sensitivity and low fidelity

26
Q

What are the two classes of baroreceptor afferent neuron?

A

A fibres and C fibres

27
Q

Are A fibres myelinated or unmyelinated?

Are C fibres myelinated or unmyelinated?

A

A fibres are myelinated

C fibres are unmyelinated

28
Q

What are the characteristics of A fibres?

A

active at resting blood pressure and fine-tune autonomic function
10%

29
Q

What are the characteristics of C fibres?

A

activated at elevated blood pressure

90%

30
Q

What do neurons of the baroreceptor reflex sense?

A

mechanical stimuli (vessel stretch)