Lecture 2: Cells ad Tissues of the Adaptive immune system Flashcards Preview

Immunology 2.0 > Lecture 2: Cells ad Tissues of the Adaptive immune system > Flashcards

Flashcards in Lecture 2: Cells ad Tissues of the Adaptive immune system Deck (27):
1

T cells mature mature under the influence of the ____ and, on stimulation by ___

thymus, antigen

2

B cels mature mainly in the ___ and give rise ot humoral immunity that involves the production fo soluble molecules _____

  • bone marrow, immunoglobulins

3

Memory cells are ____ numerous than navive cells specific for the Ag and respond ____ and ____ effectivley than do naive cells

Memory cells are more numerous than naive cells specific for the Ag respond faster and more effectively than naive 

4

CD stands for cluster of differentation, which indicates a 

defined subset of cellular surface receptors that identify cell type and stage of differentation 

5

___ and ___ are primary lymphoid organs 

Bone marrow and thymus

6

examples of secondary lymphoid organs

  • spleen
  • lymph nodes
  • mucosa-associated lymphoid tissue 

7

starting at the ___ week of gestation, some stem cells migrate to the thymus and bone marrow

13th

8

Naive lymphocytes typically die after __ to __ months if they do not recognize Antigen

1-3 months

9

what cytokines play an importan role in the devlopment of T cells from progenitor cell

  • IL-1
  • IL-2
  • IL-6
  • IL-7

10

The majority of T cells are produced ___ in human lives

early 

11

T cells which are highly reactive with self-Antigens are 

deleted by apoptosis 

12

What cytokines are importn in the development of B cells from progenitor cells

  • IL-1
  • IL-6
  • IL-7

13

Differentiation into B cells occurs within the ____ and, after birth, in the ____

fetal liver, bone marrow

14

Lymphocytes reenter the circulation from the lymph node via the efferent lymph vessels that merge into the 

thoracic duct 

15

Ag-activated B cells proliferate in _____ and mature into memory or plasma cells

Germinal centers of lymph nodes

16

In the spleen, Ag-activated B cells primarily produce Abs against mibroical 

polysaccharides

17

T cell and B cells zones of the spleen make up the 

white pulp (periarteriolar lymphoid sheath (T cells) and lymphoid follicle wiht a germinal center toward margins (B cells) 

18

Plasma cells are rarely found in the peripheral blood but they comprise from ____ % fo the bone marrow white cell count 

0.2%-2.8% of the bone marrow white cell count 

19

in the absence of Ag stimulation, follicles are _____ follicles, composed of small naive B cells or recirculating memory B cells

primary follicles

20

professional APCs

  • Dendritic cells
  • Tissue macrophages
  • B cells 

21

Only ___ can activate naive T cells

dendritic cells (DCs) 

22

To acquire Ags, DCs use ___, ___, and ____

  • Phagocytosis
  • receptor-mediated endocytosis
  • pinocytosis 

23

Classical DCs reside in 

  • Skin
  • Mucosa
  • Organ Parenchyma

24

Plasmacytoid DCs are early cellular responders to ____. They recognize ______ and produce  

  • viral infection
  • They recognize nucleic acids of intracellular viruses and produce soluble proteins called type I interferons, which have potent antiviral activities

25

besides classical and plasmacytoid DCs what are other forms of dendritc cells 

  • Populations of dendritic cells may also be derived from embryonic precursors (ex. Langerhan's cells), and during inflammation (from monocytes) 

26

Follicular dendritic cells (FDCs) bind and display 

unrprocessed antigens on their surfaces for recognition by B cells only 

27

Follicular dendritic cells (FDCs) have a remarkable ability to 

retain Ags on their cell surface for extended periods of time