Lecture 20 Flashcards
(25 cards)
describe the normal process of sexual different and the 3 levels of sexual differentitation
describe sex determination of the gonad, what is the important of the SRY gene?
what are the key cell types in the gonads (testis and ovaries)
describe the formation of internal genitalia is determined by what?
describe what hormones are produced in formation of each
describe the mullerian ducts vs wolffian ducts
so if testis are present, what happens? and if they are absent what happens/
describe the formatoin of EXTERNAL genitalia
what are the diagnostic tool sand exams we would use to assess the phenotype?
what is a virilised female?
describe undervirilsed male
describe partial androgen resistance vs complete
how do we manage these disorders?
what conditions do we screen for in nz?
how does newborn screening work in nz?
describe congenital hypothyroidism, what are the types?
what does CHT lead to untreated
how do we suspect CHT?
we screen for TSH, if its super high then she probs has hypothyroidsm
what is congential adrenal hyperplasia**
what is 210hase deficincey?
no cortisol happening because there is no 21ohase
what does elevation in 17OHP lead to in girls? what do they present with?
how do boys present with 210hase deficiency
what are the goals of treatment of 21 OHASE deficicnecy?
replace cortisol with hydrocortisone, and replace aldosterone with fludrocortisone
salt supplemetning
over replace to supress their ACTH down to nothing,
how is cortisol regulated slash produced in the body?
how do we get 17ohp build up in CAH?
