Lecture 20 - Hormonal control of ageing 1

Question 1

name the 4 “pauses” in ageing

Answer 1

somatopause
menopause
andropause
adrenopause

Question 2

in the somatotropic axis GHRH releases GH in target tissues - name an example. where does this the signal back to to reduce effect?

Answer 2

liver, hypothalamus

Question 3

give the name of the protein which is a downstream target for IGF1 in laron syndrome

Answer 3

TXNIP - thioredoxin interacting protein

Question 4

what is the shape of the curve of human GH/insulin signalling and ageing for when these hormones are most useful in life?

Answer 4

U shaped

Question 5

does GH decline with age?

Answer 5

yes