Lecture 22: HPV Vaccine Flashcards Preview

PSIO 469 Exam 04 > Lecture 22: HPV Vaccine > Flashcards

Flashcards in Lecture 22: HPV Vaccine Deck (38):
1

Cervical Cancer is __ most frequent diagnosed cancer in women worldwide.
Cervical Cancer is most commonly diagnosed cancer among women in ____ &____ _____
___ out of 10 cervical cancer deaths occurs in less _____countries

4th
Eastern & Middle Africa
9; developed

2

What is "Malignant Neoplasm?"

a tumor that tends to grow, invade, and metastasize

3

What is "HPV?"

- Human Papillomavirus
- Double stranded circular DNA episome
- Surrounded by 72 pentametic (5-sided) capsules

4

In HPV, these genes encode for capsid proteins?

L1 and L2

5

individual capsids will assemble into ___-____ ____ (___) when expressed in microbial organisms

Virus-like particles (VLPs)

6

VLPs lack:

Viral DNA

7

What is an "Oncogene?"

Gene that causes transformation of normal cells into cancerous tumor cells, especially viral gene that transforms host cell into tumor cells

8

HPV 16 accounts for nearly 50-60% of all:

Cervical Cancer

9

HPV 18 accounts for 10-20% of all:

Cervical Cancer

10

HPV 6 and 11 are associated with 90% of:

genital warts

11

The ____ separates the uterus from the vagina.
The cervix has flat ______ cells in region near vagina

cervix
squamous

12

What are "Squamous cells?"

Plate-like (thin and flat)

13

What is "Dysplasia?"

Alteration in size, shape and organization of adult cells

14

What is "Carcinoma?"

malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues

15

HPV doesn't always lead to cervical cancer.
T/F

True

16

__% are transient, asymptomatic, and resolve without treatment and HPV is no longer detectable in _____

80%
cervix

17

In women with intact immune system, HPV infection generally resolves without intervention within:

18-24 months

18

What is "LSIL?"

Low grade Squamous Intraepithelial Lesion
(aka Mild Dysplasia)

19

What is "HSIL?"

High grade Squamous Intraepithelial Lesion
(aka moderate to severe dysplasia)

20

__% of women <25 are positive for HPV.
Up to __% of sexually active college-age students are HPV infected.
__% of women >45 are positive for HPV

30%
70%
3%

21

What is a PAP Test

screening test to detect premalignant and malignant cells in the cervix

22

How does a PAP test work?

- Cells are collected from outer opening of cervix
- cell are placed on glass slide and checked for abnormalities under microscope

23

How does a flashlight- vinegar test work?

1) health worker looks at cervix with flashlight and swabs with vinegar
2) spots that run white may be precancerous legions

24

Do young women who have LSIL require treatment?

no, because it usually goes away by itself

25

If LSIL persists or progresses to HSIL then how is it treated?

- Loop Electrosurgical Excision Procedure (LEEP)
- Cryotherapy

26

What is LEEP?

A procedure where a thin wire loop carrying electric current is used to remove abnormal areas of cervix

27

What is Cryotherapy?

A procedure where abnormal tissue is frozen and later shed by the body

28

How does the HPV Vaccine work?
HPV Capsid proteins can assemble into ___-___ ______ (___)

Virus-like particles (VLPs)

29

How does the HPV Vaccine work?
Specific HPV VLPs elicit robust _____ response

Antibody

30

Gardasil includes VLPs from HPV:
how many valences is it?

16, 18, 31, 33, 45, 52, 6 and 11
9-valent

31

In June 2006, FDA approved Gardasil for females ages:

9-26

32

___% of US youths have intercourse by age 13.
___% have intercourse by Grade 12

7.4%
46.7%

33

Is it recommended after onset of sexual activity, even if there has been abnormal Pap or HPV DNA test or genital warts?

Yes, because the vaccine can protect against HPV types not already acquired

34

What is another reasons it is recommended for?
When is it not recommended?

- for immuno-suppressed women due to high risk for persistent HPV infection
- For newborn immunization because duration of protection is unclear

35

In October 2009, FDA approved Gardasil for males ages:

9-26

36

Which HPV in males gives them genital warts?

HPV 6 and 11

37

Boys are prone to HPV-related cancers as girls.
T/F

False, they are not prone

38

Boys are involved with the transmission of HPV.
T/F

True