Flashcards in Lecture 23 - Effector Mechanisms in T Cell Responses Deck (58)
Primary target of cellular immunity
Primary target of humoral immunity
Response to small extracellular pathogens, such as bacteria and fungi
Th17 neutrophilic response
Response to large extracellular parasites, eg: helminth worms
Th2-mediated IL-5 and eosinophil response
Response to cytosolic intracellular pathogens
Response to intracellular pathogens in phagocytic compartments
Th1-mediated IFNg responses
What does LFA-1 stand for?
Leukocyte function antigen 1
Which cells express selectins?
Cells to which T cells will adhere
Which cells express E- and P-selectin?
Which T cell surface molecule binds to E- and P-selectin?
Which selectins do epithelial cells express?
P- and E-selectins
Activation signals secreted by epithelial cells
Epithelial cell adhesion molecules
Which cells express ICAM-1 and VCAM-1?
What induces epithelial cells to express T cell adhesion molecules?
What detects CCL17 and CCL27?
CCR4 and CCR10
What binds ICAM-1?
What binds VCAM-1?
Factor expressed by endothelial cells in GALT for T cell rolling
MAdCAM-1 and P-selectin
What expresses MAdCAM-1 and P-selectin?
Endothelial cells in GALT
MAdCAM-1 ligand for rolling
Inactive alpha4 beta7 integrin
T cell activation factor in GALT
CCL25 (produced by enterocytes)
What expresses CCL25?
Activates T cells in GALT
Factor expressed by GALT endothelial cells for adhesion
MAdCAM-1 ligand for adhesion
Active alpha4 beta7 integrin
How is tissue-specific information imprinted in organ-dwelling lymph nodes?
A factor from the organ that the lymph node drains biases T cells to express certain chemokine receptors
Example of imprinting of tissue-specific information in an organ-dwelling lymph node
1) In a lymph node that drains the skin, vitamin D metabolites act on dendritic cells and stromal cells
2) DCs, stromal cells secrete factors, cause T cell upregulation of CCR4, CCR10, PSGL-1.
3) T cells migrate to skin
Metabolites that imprint on lymph nodes gut addressins
Vitamin A metabolites
What causes T cells to differentiate into Th1?
1) Dendritic cell presents antigen to naive T cell on MHCII
2) DC or macrophage releases IL-12
3) NK cell releases IFNg
4) IL-12 activates STAT4 transcription factor
5) IFNg activates STAT1, T-bet transcription factors