Lecture 23 - Effector Mechanisms in T Cell Responses Flashcards Preview

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1

Primary target of cellular immunity

Intracellular pathogens

2

Primary target of humoral immunity

Extracellular pathogens

3

Response to small extracellular pathogens, such as bacteria and fungi

Th17 neutrophilic response

4

Response to large extracellular parasites, eg: helminth worms

Th2-mediated IL-5 and eosinophil response

5

Response to cytosolic intracellular pathogens

CD8+

6

Response to intracellular pathogens in phagocytic compartments

Th1-mediated IFNg responses

7

What does LFA-1 stand for?

Leukocyte function antigen 1

8

Which cells express selectins?

Cells to which T cells will adhere

9

Which cells express E- and P-selectin?

Epithelial cells

10

Which T cell surface molecule binds to E- and P-selectin?

PSGL-1

11

Which selectins do epithelial cells express?

P- and E-selectins

12

Activation signals secreted by epithelial cells

CCL17, CCL27

13

Epithelial cell adhesion molecules

ICAM-1, VCAM-1

14

Which cells express ICAM-1 and VCAM-1?

Endothelial cells

15

What induces epithelial cells to express T cell adhesion molecules?

TNFa, IFNg

16

What detects CCL17 and CCL27?

CCR4 and CCR10

17

What binds ICAM-1?

LFA-1

18

What binds VCAM-1?

VLA-4

19

Factor expressed by endothelial cells in GALT for T cell rolling

MAdCAM-1 and P-selectin

20

What expresses MAdCAM-1 and P-selectin?

Endothelial cells in GALT

21

MAdCAM-1 ligand for rolling

Inactive alpha4 beta7 integrin

22

T cell activation factor in GALT

CCL25 (produced by enterocytes)

23

What expresses CCL25?

Enterocytes.
Activates T cells in GALT

24

Factor expressed by GALT endothelial cells for adhesion

MAdCAM-1

25

MAdCAM-1 ligand for adhesion

Active alpha4 beta7 integrin

26

How is tissue-specific information imprinted in organ-dwelling lymph nodes?

A factor from the organ that the lymph node drains biases T cells to express certain chemokine receptors

27

Example of imprinting of tissue-specific information in an organ-dwelling lymph node
1)
2)
3)

1) In a lymph node that drains the skin, vitamin D metabolites act on dendritic cells and stromal cells
2) DCs, stromal cells secrete factors, cause T cell upregulation of CCR4, CCR10, PSGL-1.
3) T cells migrate to skin

28

Metabolites that imprint on lymph nodes gut addressins

Vitamin A metabolites

29

What causes T cells to differentiate into Th1?
1)
2)
3)
4)
5)

1) Dendritic cell presents antigen to naive T cell on MHCII
2) DC or macrophage releases IL-12
3) NK cell releases IFNg
4) IL-12 activates STAT4 transcription factor
5) IFNg activates STAT1, T-bet transcription factors

30

How does Th1 amplification occur?

Th1 releases IFNg, autostimulates