Lecture 24

Question 1

What are mutations? What’s the difference between somatic and germline mutations?

Answer 1

• permanent changes in DNA
• germline = in gametes, is inheritable
• somatic = acquired via damage

Question 2

What are the two ways we classify mutations?

Answer 2

• dominant vs recessive
• loss of function vs gain of function

Question 3

What is the difference between a monogenic and polygenic disorder?

Answer 3

• monogenic = one gene is responsible
• polygenic = multipe genes responsible

Question 4

For most diseases, having a disease-related variation does not mean you will get the disease. This is because genetic disorders are…

Answer 4

Probabilistic