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Flashcards in Lecture 3 Deck (16)
1

What part of the mitochondria is responsible for oxidative phosphorylation?

Inner membrance

2

What part of the mitochondria is responsible for the electron transport chain?

Intermembrane space

3

What part of the mitochondria is responsible for the TCA cycle and fatty-acid oxidation?

Matrix

4

How many transcriptional starting sites are there for mitochondrial DNA?

3

5

What is the total number of genes encoded by mitochondrial DNA?

37

6

How many protein complexes in the inner mitochondrial membrane are involved with the ETC?

4

7

What are the two origin sites for mitochondrial DNA transcription?

OH and OL

8

What is mitochondrial mosaicism?

Different cells that derive from a same parent cell contain different (mutant or nonmutant) mitochondria

9

What is MERRF?

Myoclonic Epilepsy associated with Ragged Red Fibers

10

What is MELAS?

Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes)

11

What is LHON?

Leber Hereditary Optic Neuropathy

12

A-to-G mutation at nucleotide 8344 results in which disease?

MERRF

13

A-to-G mutation at nucleotide 3243 or G-to-A mutation at nucleotide 4332 results in which disease?

MELAS

14

G-to-A mutation at nucleotide 11778 results in which disease?

LHON

15

What mitochondrial diseases are caused by a deletion mutation in mtDNA?

KSS (Kearns-Sayre syndrome), Pearson syndrome, & CPEO (Chronic Progressive Opthalmoplegia)

16

Name a mitochondrial disease caused by a mutation in a nuclear gene?

Alpers/Ataxia (mutations in POLG)