Flashcards in Lecture 3 Deck (16)
What part of the mitochondria is responsible for oxidative phosphorylation?
What part of the mitochondria is responsible for the electron transport chain?
What part of the mitochondria is responsible for the TCA cycle and fatty-acid oxidation?
How many transcriptional starting sites are there for mitochondrial DNA?
What is the total number of genes encoded by mitochondrial DNA?
How many protein complexes in the inner mitochondrial membrane are involved with the ETC?
What are the two origin sites for mitochondrial DNA transcription?
OH and OL
What is mitochondrial mosaicism?
Different cells that derive from a same parent cell contain different (mutant or nonmutant) mitochondria
What is MERRF?
Myoclonic Epilepsy associated with Ragged Red Fibers
What is MELAS?
Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes)
What is LHON?
Leber Hereditary Optic Neuropathy
A-to-G mutation at nucleotide 8344 results in which disease?
A-to-G mutation at nucleotide 3243 or G-to-A mutation at nucleotide 4332 results in which disease?
G-to-A mutation at nucleotide 11778 results in which disease?
What mitochondrial diseases are caused by a deletion mutation in mtDNA?
KSS (Kearns-Sayre syndrome), Pearson syndrome, & CPEO (Chronic Progressive Opthalmoplegia)