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Flashcards in Lecture 3 Deck (10):
1

What is the holistic approach in systems biology?

The all at once approach; required as some properties of a system can emerge from the interaction of components

2

What is meant by "Capturing the Proteome"

Identifying the total proteins of a cell at a single point in time (which is thusfar technically challenging)

2

List 3 clinical implications of bioinformatics

Diagnosis of genetic disease and disease risk

Pharmacogenomics; predicting patient response - personalised medicine

Gene therepy, where thereputic target is a specific gene

3

What is homology modelling?

Homologous structures may have similar structures

This means an atomic level model of a target protein can be made from its primary sequence and experimental 3D data from a related homologous protein, the template

4

How is the potential proteome determined?

Inferred from genome sequence

5

What is a feature of amino acids with chemically similar side chains?

They substitute more readily

6

What is the reductionist approach in systems biology?

The breaking down (gene knockouts to disrupt biochemical pathways) of a biological system to understand the individual components

7

What is the primary database for protein structures?

wwPDB (World Wide Protein Data Bank)

9

What is meant by "Transcriptome"?

The transcriptome encompases the actual proteome (Translation is dependent on transcription)

10

What are 3 data resources for proteomics?

Genome sequences

Transcriptomes (microarray/RNAseq)

Protein Mass Spectrometry