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Flashcards in Lecture 3 Deck (12)
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1

Cytokine production

Soluble signals that coordinate immune cell function/activation

2

Cytokines

Small soluble proteins rapidly secreted by one cell

3

Cytokine function

Alter the behaviour/properties of cell itself or another cell

4

Ways cytokines act (3)

1) Autocrine action: released, but bind to receptor on the cell that produced them

2) Paracrine action: released to effect nearby cells

3)Endocrine action: released into the bloodstream to effect distant cells

5

Interleukin (IL)

- Type of cytokine

- General class of signals (small soluble secreted proteins) that can act between immune cells

- Has many different effects

- IL-2 & IL-6 = early alarm cytokines

6

Chemokines

- Type of IL

- Some specifically signal cells to migrate towards the source of the chemokine (IL-8)

7

Tumour necrosis factor family (TNF_)

- Battle cytokines secreted mainly by macrophages and T-helper cells

- TNF(alpha) = early alarm cytokine

8

Interferons

Battle cytokines

9

Alpha & beta interferons

Secreted by viral infected cells to warn neighbouring cells

10

Gamma interferons

Battle cytokines secreted by T-helper cells to activate macrophages

11

Opsonization

- Process where proteins “decorate” the bacteria to signal that if should be eaten

- Alteration of the pathogen or particle surface so that it can be engulfed by a phagocytic cell

12

MAC

Membrane attack complex