Lecture 3 - Cells and Tissues of the Immune System 2 Flashcards
Four paradigms of the immune system
1) Immune recognition
2) Immune effector function
3) Immune regulation
4) Immune memory
Is there more eukaryotic or prokaryotic DNA in a human body?
Prokaryotic
Is inside the mouth inside the body?
No
Definition of ‘inside the body’
When the epithelial barrier has been surpassed
Why is a foetus of interest to immunologists?
Despite the foetus having a different genetic code to the mother, the foetus is not attacked by the immune system in implantation and growth
Method of improving IVF outcomes
Injure epithelium of womb
Inflammation might be important for pregnancy
Cardinal signs of inflammation 1) 2) 3) 4) 5)
1) Dolor
2) Calor
3) Rubor
4) Tumor
5) Function laesia
What is cognate interaction?
Interaction between antigen-presenting cell and naive T cell bearing receptor for presented antigen
Structure of naive T cell Vs activated T cell
Naive T cell is mostly nucleus
Activated T cell has more cytoplasm, denser nucleus
Immunopathology
Damage to body from immune response
Example of immunopathology
Hepatitis
Hepatitis doesn’t damage host hepatocytes
CD8+ response to hepatitis infection is what causes damage
Innate immune effector mechanisms
1)
2)
3)
1) Phagocytosis
2) Microbicidal agents
3) Complement
How are the innate and adaptive immune systems bridged?
1) Dendritic cell phagocytoses antigen
2) Travels to local lymph node
3) Presents to naive T cells
Antibody functions
1)
2)
3)
1) Neutralisation of toxins
2) Opsonisation
3) Complement activation
Stages of T cell immune response
1)
2)
3)
1) Expansion
2) Contraction
3) Memory
