Lecture 34: Diabetes Mellitus 1

Question 1

What causes Type 1 diabetes?

Answer 1

Absolute deficiency of insulin caused by autoimmune attack on islet B cells of the pancreas

Question 2

What might result from Type 1?

Answer 2

Insulitis

Question 3

Which diabetes type had strong genetic influence?

Answer 3

Type 2

Question 4

What is the most common type of diabetes?

Answer 4

Type 2

Question 5

What’s an acute complication of Type 1?

Answer 5

Ketoacidosis

Question 6

Which cycle stimulates anabolism?

Answer 6

Feed cycle

Question 7

What is the first organ to respond to the influx of nutrients after a meal?

Answer 7

Liver

Question 8

What follows the feed cycle, so long as the person is non-diabetic?

Answer 8

Fed state

Question 9

Hyperglycemia is resultant from diabetes, why?

Answer 9

Glucose production increases, and GLUT4 receptors decrease the glucose uptake

Question 10

Ketonemia results from?

Answer 10

Excessive mobilization of fatty acids

Question 11

How are ketone bodies formed from ketonemia?

Answer 11

Beta oxidation of fatty acids releases Acetyl CoA

Question 12

Ketonemia is particularly present in Type…?

Answer 12

1

Question 13

Why is Ketonemia more characteristic of type 1, not 2?

Answer 13

Insulin is present in two, and that inhibits ketogenesis

Question 14

Signs of diabetes?

Answer 14

Blurry vision, yeast infections

Question 15

How is Diabetic Ketoacidosis treated?

Answer 15

Via Fluid and Electrolyte replacement, coupled with admin of short acting insulin

Question 16

Non-ketoacidotic comas (DKA) are most common in which type of DM?

Answer 16

Type 2

Question 17

Hyperglycemic coma’s are most common in which type?

Answer 17

Type 1

Question 18

What is Gestational Diabetes?

Answer 18

Pregnant woman experiences onset of DM for the first time during pregnancy

Question 19

Symptoms of LADA are the same as which DM type?

Answer 19

Type 2

Question 20

What age group do we diagnose lada?

Answer 20

30 years

Question 21

Insulin resistance alone doesn’t lead to type 2 DM, what else does it need?

Answer 21

Impaired B cell function

Question 22

The symptom of insulin resistance is?

Answer 22

Acanthosis nagricans, dark patches around skin fold areas