Lecture3: Posterior Pituitary Gland Flashcards
The posterior pituitary lies below the hypothalamus and forms the…?
Neurohypophysis
What is ADH’s target organs?
Blood vessels and the kidneys
What does ADH do to blood vessels?
Constricts them
What does ADH do to the kidney?
Increase H2O reabsorption
How does ADH increase water reabsorption by the kidney?
Acts on the distal portions of nephrons
Which hormone has an anti diuretic effect?
ADH
Vasopressin is the primary endocrine factor that regulates…?
Urinary H2O loss and balance
How does ADH cause vasoconstriction?
It binds to V1 receptors
Why is the Vasoconstrictor effect of ADH important?
Manages arterial pressure in hypotensive cases like Hemorrhage
Why is it important to develop drugs that bind to V2 receptors?
To treat diabetes insipidus without adverse effect
What is the most important regulator of Vasopressin secretion?
Plasma Osmlality
What is Diabetes Insipidus?
Insufficient ADH secreted by pituitary gland leads to the kidneys producing a lot of urine
If the cause of diabetes is cranial, what happens to the urine?
Becomes very concentrated
If cause of diabetes is nephrogenic, what happens to urine?
No response
