Lecture 36 - mechanisms of addiction Flashcards Preview

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Flashcards in Lecture 36 - mechanisms of addiction Deck (7):
1

describe the reward pathway

VTA
DA of Medial forebrain bundle
NA
Prefrontal Cortex/Cortical/Limbic systems

Behavioral changes

2

molecular changes in addiction

CREB
cAMP
gene transcription
changes to cell function
Neural plasticity

3

Cocaine --
Sites of action
Mechanism

Binding Sites -- Caudate Nucleus, VTA and NA

Mechanism -- DA reuptake transporters antagonist

4

Amphetamine/Methamphetamine --

Mechanism

taken up into the synapse via the DA transporters

Bind at the VMA, block vesicles from filling with DA

DA concentration overloads the synapse

Reverses the action of the DA reuptake transporters

5

Opiates
Locations of activity
mechanism

thalamus, VTA, NA -- euphoria

Cortical regions -- mediate the analgesia and sedation

Three-way in the VTA/Nucleus Accumbens
Inhibit GABA release (which is tonically inhibiting DA release)
therefore increases DA release





6

Marijuana

what is the endogenous ligand to the cannabinoid receptor?

mechanism of action

Anandamide

Mechanism -- The three-way;

THC mediated decrease in Tonic GABA inhibition

Increasing DA release

7

nicotine --
mechanism

Binds N ACH receptors on the DA neurons; inducing DA release
Binds with higher affinity than ACH
Increases DA releases