lecture 31 - Schizophrenic Spectrum D/o

Question 1

Criteria for schizophrenia

Answer 1

2 more of the following sympotms x 1 month; but overall must have disturbancse for 6 months

Positive sx – dellusions, hallucinations, d/o speech, d/o behavior

negative sx – alogia, avolition, flat affect

Question 2

other sx of schizophrenia

common first sign

Answer 2

Comon first line – social withdrawal

other sx – relationship problems, cognitive problems

overall very heterogeneous

Question 3

what is schizoaffective s/o

Answer 3

mixed btw BP and SChizo

a combination of BP d/o and schizo

	- - delusions or hallucinations for greater than 2 weeks, without mood symptoms 
	- - mood symptoms when present, are overall present for majority of total duration (pervasive mood sx)

Question 4

what is hte Modified dopamine hypothesis

how does it relate to positive and negative sx

Answer 4

• Positive symptoms may be mediated by dopamine excess in limbic regions

Negative symptoms may be mediated by hypodopaminergic in prefrontal areas

Question 5

course and development of schizo –

age of onset
how long does it last ?
suicide risk ?
negative prognostic factors ?

Answer 5

16-14 yo
many kids during transition to college
life long but episodic
20x suicide risk (5-6% of patients)

negative factors: early onset, insiduous onset, autism, poor support and social symtms

Question 6

• Treatment approaches

Answer 6

• Antipsyhcotic meds

	* Psychosocial treatments
	* CBT 
	* Social skills training 
	* Family psychosocial intervention 

Supoorted employment